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dc.contributor.authorHarries, Men
dc.contributor.authorChamberlain, Samuelen
dc.contributor.authorRedden, SAen
dc.contributor.authorOdlaug, BLen
dc.contributor.authorBlum, AWen
dc.contributor.authorGrant, JEen
dc.date.accessioned2017-11-06T15:48:11Z
dc.date.available2017-11-06T15:48:11Z
dc.date.issued2017-11-30en
dc.identifier.issn0925-4927
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/268116
dc.description.abstractExcoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life. No statistically significant differences in basal ganglia (caudate, putamen, and nucleus accumbens) structural volumes were found between groups. In individuals with SPD, increasing impulsiveness correlated positively with increased cortical thickness in the left insula, and skin picking severity correlated negatively with cortical thickness in the left supramarginal gyrus and a region encompassing the right inferior parietal, right temporal and right supramarginal gyrus. This study suggests similarities and differences exist in symptomology between SPD and the other obsessive-compulsive and related disorders. Additional neuroimaging research is needed to better delineate the underlying neurobiology of SPD.
dc.description.sponsorshipMr. Michael Harries, Ms. Sarah Redden and Mr. Austin Blum report no conflicts of interest. Dr. Samuel Chamberlain consults for Cambridge Cognition and Shire. He also receives funding from the Wellcome Trust Clinical Fellowship (110049/Z/15/Z). Dr. Brian Odlaug has received research funding from the TLC Foundation for Body Focused Repetitive Behaviors and has received royalties from Oxford University Press and Johns Hopkins Press. He has consulted for and is currently employed by H. Lundbeck A/S. His contribution to this project concluded prior to his employment with H. Lundbeck A/S. Dr. Jon Grant currently has research grants from the National Center for Responsible Gaming, Brainsway, the American Foundation for Suicide Prevention, the TLC Foundation for Body Focused Repetitive Behaviors, Forest Takeda and Psyadon Pharmaceuticals. He receives yearly compensation from Springer Publishing for acting as Editor-in-Chief of the Journal of Gambling Studies and has received royalties from Oxford University Press, Johns Hopkins Press, American Psychiatric Publishing, Inc., Norton Press, and McGraw Hill.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectskin picking disorderen
dc.subjectobsessive-compulsiveen
dc.subjectcortical thicknessen
dc.subjectstructural volumeen
dc.subjectbrain imagingen
dc.titleA structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severityen
dc.typeArticle
prism.endingPage30
prism.publicationDate2017en
prism.publicationNamePsychiatry Research - Neuroimagingen
prism.startingPage26
prism.volume269en
dc.identifier.doi10.17863/CAM.14333
dcterms.dateAccepted2017-09-07en
rioxxterms.versionofrecord10.1016/j.pscychresns.2017.09.006en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-11-30en
dc.contributor.orcidChamberlain, Samuel [0000-0001-7014-8121]
dc.identifier.eissn1872-7506
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (110049/Z/15/Z)
cam.issuedOnline2017-09-08en
rioxxterms.freetoread.startdate2018-09-08


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Attribution-NonCommercial-NoDerivatives 4.0 International
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