M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
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Authors
Bradley, Sophie J
Sanger, Helen E
Verity, Nicholas
Mogg, Adrian J
White, David J
Moreno, Julie A
Macedo-Hatch, Timothy
Edwards, Jennifer M
Wess, Jurgen
Pawlak, Robert
Read, David J
Broad, Lisa M
Felder, Christian C
Tobin, Andrew B
Publication Date
2017-02Journal Title
The Journal of clinical investigation
ISSN
0021-9738
Volume
127
Issue
2
Pages
487-499
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Bradley, S. J., Bourgognon, J., Sanger, H. E., Verity, N., Mogg, A. J., White, D. J., Butcher, A., et al. (2017). M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.. The Journal of clinical investigation, 127 (2), 487-499. https://doi.org/10.1172/jci87526
Keywords
Hippocampus, Animals, Mice, Knockout, Humans, Mice, Alzheimer Disease, Prion Diseases, Memory Disorders, Quinolines, Receptor, Muscarinic M1, Allosteric Regulation
Sponsorship
ECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (647479)
Identifiers
External DOI: https://doi.org/10.1172/jci87526
This record's URL: https://www.repository.cam.ac.uk/handle/1810/268511
Rights
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International
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