Anion Recognition as a Supramolecular Switch of Cell Internalization.
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Authors
Rodríguez, Jéssica
Publication Date
2017-01Journal Title
Journal of the American Chemical Society
ISSN
0002-7863
Volume
139
Issue
1
Pages
55-58
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Rodríguez, J., Mosquera, J., Couceiro, J. R., Nitschke, J., Vázquez, M. E., & Mascareñas, J. L. (2017). Anion Recognition as a Supramolecular Switch of Cell Internalization.. Journal of the American Chemical Society, 139 (1), 55-58. https://doi.org/10.1021/jacs.6b11103
Abstract
The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.
Keywords
Vero Cells, Cell Membrane, Animals, Cercopithecus aethiops, Anions, Macromolecular Substances, Molecular Structure
Sponsorship
EPSRC (EP/K039520/1)
Identifiers
External DOI: https://doi.org/10.1021/jacs.6b11103
This record's URL: https://www.repository.cam.ac.uk/handle/1810/268514
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