Anion Recognition as a Supramolecular Switch of Cell Internalization.

Rodríguez, Jéssica; Mosquera, Jesús; Couceiro, José R; Nitschke, Jonathan; Vázquez, M Eugenio; Mascareñas, José L

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Authors

Rodríguez, Jéssica

Mosquera, Jesús

Couceiro, José R

Nitschke, Jonathan

Vázquez, M Eugenio

Mascareñas, José L

Publication Date

2017-01-11

Journal Title

J Am Chem Soc

ISSN

0002-7863

Publisher

American Chemical Society (ACS)

Volume

139

Issue

Pages

55-58

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

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Citation

Rodríguez, J., Mosquera, J., Couceiro, J. R., Nitschke, J., Vázquez, M. E., & Mascareñas, J. L. (2017). Anion Recognition as a Supramolecular Switch of Cell Internalization.. J Am Chem Soc, 139 (1), 55-58. https://doi.org/10.1021/jacs.6b11103

Abstract

The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.

Keywords

Vero Cells, Cell Membrane, Animals, Anions, Macromolecular Substances, Molecular Structure, Chlorocebus aethiops

Sponsorship

Engineering and Physical Sciences Research Council (EP/K039520/1)

Identifiers

External DOI: https://doi.org/10.1021/jacs.6b11103

This record's URL: https://www.repository.cam.ac.uk/handle/1810/268514

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