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dc.contributor.authorEhret, Georg Ben
dc.contributor.authorFerreira, Teresaen
dc.contributor.authorChasman, Daniel Ien
dc.contributor.authorJackson, Anne Uen
dc.contributor.authorSchmidt, Ellen Men
dc.contributor.authorJohnson, Tobyen
dc.contributor.authorThorleifsson, Gudmaren
dc.contributor.authorLuan, Jian'anen
dc.contributor.authorDonnelly, Lousie Aen
dc.contributor.authorKanoni, Stavroulaen
dc.contributor.authorPetersen, Ann-Kristinen
dc.contributor.authorPihur, Vasylen
dc.contributor.authorStrawbridge, Rona Jen
dc.contributor.authorShungin, Dmitryen
dc.contributor.authorHughes, Maria Fen
dc.contributor.authorMeirelles, Osorioen
dc.contributor.authorKaakinen, Marikaen
dc.contributor.authorBouatia-Naji, Nabilaen
dc.contributor.authorKristiansson, Katien
dc.contributor.authorShah, Soniaen
dc.contributor.authorKleber, Marcus Een
dc.contributor.authorGuo, Xiuqingen
dc.contributor.authorLyytikäinen, Leo-Pekkaen
dc.contributor.authorFava, Cristianoen
dc.contributor.authorEriksson, Niclasen
dc.contributor.authorNolte, Ilja Men
dc.contributor.authorMagnusson, Patrik Ken
dc.contributor.authorSalfati, Elias Len
dc.contributor.authorRallidis, Loukianos Sen
dc.contributor.authorTheusch, Elizabethen
dc.contributor.authorSmith, Andrew JPen
dc.contributor.authorFolkersen, Lasseen
dc.contributor.authorWitkowska, Kateen
dc.contributor.authorPers, Tune Hen
dc.contributor.authorJoehanes, Robyen
dc.contributor.authorKim, Stuart Ken
dc.contributor.authorLataniotis, Lazarosen
dc.contributor.authorJansen, Ricken
dc.contributor.authorJohnson, Andrew Den
dc.contributor.authorWarren, Helenen
dc.contributor.authorKim, Young Jinen
dc.contributor.authorZhao, Weien
dc.contributor.authorWu, Yingen
dc.contributor.authorTayo, Bamidele Oen
dc.contributor.authorBochud, Murielleen
dc.contributor.authorCHARGE-EchoGen consortium,en
dc.contributor.authorCHARGE-HF consortium,en
dc.contributor.authorWellcome Trust Case Control Consortium,en
dc.contributor.authorAbsher, Devinen
dc.contributor.authorAdair, Linda Sen
dc.contributor.authorAmin, Najafen
dc.contributor.authorArking, Dan Een
dc.contributor.authorAxelsson, Tomasen
dc.contributor.authorBaldassarre, Damianoen
dc.contributor.authorBalkau, Beverleyen
dc.contributor.authorBandinelli, Stefaniaen
dc.contributor.authorBarnes, Michael Ren
dc.contributor.authorBarroso, Inesen
dc.contributor.authorBevan, Stephenen
dc.contributor.authorBis, Joshua Cen
dc.contributor.authorBjornsdottir, Gydaen
dc.contributor.authorBoehnke, Michaelen
dc.contributor.authorBoerwinkle, Ericen
dc.contributor.authorBonnycastle, Lori Len
dc.contributor.authorBoomsma, Dorret Ien
dc.contributor.authorBornstein, Stefan Ren
dc.contributor.authorBrown, Morris Jen
dc.contributor.authorBurnier, Michelen
dc.contributor.authorCabrera, Claudia Pen
dc.contributor.authorChambers, John Cen
dc.contributor.authorChang, I-Shouen
dc.contributor.authorCheng, Ching-Yuen
dc.contributor.authorChines, Peter Sen
dc.contributor.authorChung, Ren-Huaen
dc.contributor.authorCollins, Francis Sen
dc.contributor.authorConnell, John Men
dc.contributor.authorDöring, Angelaen
dc.contributor.authorDallongeville, Jeanen
dc.contributor.authorDanesh, Johnen
dc.contributor.authorde Faire, Ulfen
dc.contributor.authorDelgado, Gracielaen
dc.contributor.authorDominiczak, Anna Fen
dc.contributor.authorDoney, Alex SFen
dc.contributor.authorDrenos, Fotiosen
dc.contributor.authorEdkins, Sarahen
dc.contributor.authorEicher, John Den
dc.contributor.authorElosua, Robertoen
dc.contributor.authorEnroth, Stefanen
dc.contributor.authorErdmann, Jeanetteen
dc.contributor.authorEriksson, Peren
dc.contributor.authorEsko, Tonuen
dc.contributor.authorEvangelou, Evangelosen
dc.contributor.authorEvans, Alunen
dc.contributor.authorFall, Toveen
dc.contributor.authorFarrall, Martinen
dc.contributor.authorFelix, Janine Fen
dc.contributor.authorFerrières, Jeanen
dc.contributor.authorFerrucci, Luigien
dc.contributor.authorFornage, Myriamen
dc.contributor.authorForrester, Terrenceen
dc.contributor.authorFranceschini, Noraen
dc.contributor.authorDuran, Oscar H Francoen
dc.contributor.authorFranco-Cereceda, Andersen
dc.contributor.authorFraser, Ross Men
dc.contributor.authorGanesh, Santhi Ken
dc.contributor.authorGao, Heen
dc.contributor.authorGertow, Karlen
dc.contributor.authorGianfagna, Francescoen
dc.contributor.authorGigante, Brunaen
dc.contributor.authorGiulianini, Francoen
dc.contributor.authorGoel, Anujen
dc.contributor.authorGoodall, Alison Hen
dc.contributor.authorGoodarzi, Mark Oen
dc.contributor.authorGorski, Mathiasen
dc.contributor.authorGräßler, Jürgenen
dc.contributor.authorGroves, Christopheren
dc.contributor.authorGudnason, Vilmunduren
dc.contributor.authorGyllensten, Ulfen
dc.contributor.authorHallmans, Göranen
dc.contributor.authorHartikainen, Anna-Liisaen
dc.contributor.authorHassinen, Maijaen
dc.contributor.authorHavulinna, Aki Sen
dc.contributor.authorHayward, Carolineen
dc.contributor.authorHercberg, Sergeen
dc.contributor.authorHerzig, Karl-Heinzen
dc.contributor.authorHicks, Andrew Aen
dc.contributor.authorHingorani, Aroon Den
dc.contributor.authorHirschhorn, Joel Nen
dc.contributor.authorHofman, Alberten
dc.contributor.authorHolmen, Josteinen
dc.contributor.authorHolmen, Oddgeir Lingaasen
dc.contributor.authorHottenga, Jouke-Janen
dc.contributor.authorHoward, Philen
dc.contributor.authorHsiung, Chao Aen
dc.contributor.authorHunt, Steven Cen
dc.contributor.authorIkram, M Arfanen
dc.contributor.authorIllig, Thomasen
dc.contributor.authorIribarren, Carlosen
dc.contributor.authorJensen, Richard Aen
dc.contributor.authorKähönen, Mikaen
dc.contributor.authorKang, Hyunen
dc.contributor.authorKathiresan, Sekaren
dc.contributor.authorKeating, Brendan Jen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorKim, Yun Kyoungen
dc.contributor.authorKim, Ericen
dc.contributor.authorKivimaki, Mikaen
dc.contributor.authorKlopp, Normanen
dc.contributor.authorKolovou, Genovefaen
dc.contributor.authorKomulainen, Pirjoen
dc.contributor.authorKooner, Jaspal Sen
dc.contributor.authorKosova, Gulumen
dc.contributor.authorKrauss, Ronald Men
dc.contributor.authorKuh, Dianaen
dc.contributor.authorKutalik, Zoltanen
dc.contributor.authorKuusisto, Johannaen
dc.contributor.authorKvaløy, Kirstien
dc.contributor.authorLakka, Timo Aen
dc.contributor.authorLee, Nanette Ren
dc.contributor.authorLee, I-Teen
dc.contributor.authorLee, Wen-Janeen
dc.contributor.authorLevy, Danielen
dc.contributor.authorLi, Xiaohuien
dc.contributor.authorLiang, Kae-Woeien
dc.contributor.authorLin, Honghuangen
dc.contributor.authorLin, Lien
dc.contributor.authorLindström, Jaanaen
dc.contributor.authorLobbens, Stéphaneen
dc.contributor.authorMännistö, Satuen
dc.contributor.authorMüller, Gabrieleen
dc.contributor.authorMüller-Nurasyid, Martinaen
dc.contributor.authorMach, Françoisen
dc.contributor.authorMarkus, Hughen
dc.contributor.authorMarouli, Eirinien
dc.contributor.authorMcCarthy, Mark Ien
dc.contributor.authorMcKenzie, Colin Aen
dc.contributor.authorMeneton, Pierreen
dc.contributor.authorMenni, Cristinaen
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorMijatovic, Vladanen
dc.contributor.authorMoilanen, Leenaen
dc.contributor.authorMontasser, May Een
dc.contributor.authorMorris, Andrew Den
dc.contributor.authorMorrison, Alanna Cen
dc.contributor.authorMulas, Antonellaen
dc.contributor.authorNagaraja, Ramaiahen
dc.contributor.authorNarisu, Narisuen
dc.contributor.authorNikus, Kjellen
dc.contributor.authorO'Donnell, Christopher Jen
dc.contributor.authorO'Reilly, Paul Fen
dc.contributor.authorOng, Kennethen
dc.contributor.authorPaccaud, Freden
dc.contributor.authorPalmer, Cameron Den
dc.contributor.authorParsa, Afshinen
dc.contributor.authorPedersen, Nancy Len
dc.contributor.authorPenninx, Brenda Wen
dc.contributor.authorPerola, Markusen
dc.contributor.authorPeters, Annetteen
dc.contributor.authorPoulter, Neilen
dc.contributor.authorPramstaller, Peter Pen
dc.contributor.authorPsaty, Bruce Men
dc.contributor.authorQuertermous, Thomasen
dc.contributor.authorRao, Dabeeru Cen
dc.contributor.authorRasheed, Asifen
dc.contributor.authorRayner, N William NWRen
dc.contributor.authorRenström, Fridaen
dc.contributor.authorRettig, Raineren
dc.contributor.authorRice, Kenneth Men
dc.contributor.authorRoberts, Roberten
dc.contributor.authorRose, Lynda Men
dc.contributor.authorRossouw, Jacquesen
dc.contributor.authorSamani, Nilesh Jen
dc.contributor.authorSanna, Serenaen
dc.contributor.authorSaramies, Joukoen
dc.contributor.authorSchunkert, Heriberten
dc.contributor.authorSebert, Sylvainen
dc.contributor.authorSheu, Wayne H-Hen
dc.contributor.authorShin, Young-Ahen
dc.contributor.authorSim, Xuelingen
dc.contributor.authorSmit, Johannes Hen
dc.contributor.authorSmith, Albert Ven
dc.contributor.authorSosa, Maria Xen
dc.contributor.authorSpector, Tim Den
dc.contributor.authorStančáková, Alenaen
dc.contributor.authorStanton, Aliceen
dc.contributor.authorStirrups, Kathleenen
dc.contributor.authorStringham, Heather Men
dc.contributor.authorSundstrom, Johanen
dc.contributor.authorSwift, Amy Jen
dc.contributor.authorSyvänen, Ann-Christineen
dc.contributor.authorTai, E-Shyongen
dc.contributor.authorTanaka, Toshikoen
dc.contributor.authorTarasov, Kirill Ven
dc.contributor.authorTeumer, Alexanderen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorTobin, Martin Den
dc.contributor.authorTremoli, Elenaen
dc.contributor.authorUitterlinden, Andre Gen
dc.contributor.authorUusitupa, Mattien
dc.contributor.authorVaez, Ahmaden
dc.contributor.authorVaidya, Dhananjayen
dc.contributor.authorvan Duijn, Cornelia Men
dc.contributor.authorvan Iperen, Erik PAen
dc.contributor.authorVasan, Ramachandran Sen
dc.contributor.authorVerwoert, Germaine Cen
dc.contributor.authorVirtamo, Jarmoen
dc.contributor.authorVitart, Veroniqueen
dc.contributor.authorVoight, Benjamin Fen
dc.contributor.authorVollenweider, Peteren
dc.contributor.authorWagner, Alineen
dc.contributor.authorWain, Louise Ven
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorWatkins, Hughen
dc.contributor.authorWeder, Alan Ben
dc.contributor.authorWestra, Harm-Janen
dc.contributor.authorWilks, Rainforden
dc.contributor.authorWilsgaard, Tomen
dc.contributor.authorWilson, James Fen
dc.contributor.authorWong, Tien Yen
dc.contributor.authorYang, Tsun-Poen
dc.contributor.authorYao, Jieen
dc.contributor.authorYengo, Loicen
dc.contributor.authorZhang, Weihuaen
dc.contributor.authorZhao, Jing Huaen
dc.contributor.authorZhu, Xiaofengen
dc.contributor.authorBovet, Pascalen
dc.contributor.authorCooper, Richard Sen
dc.contributor.authorMohlke, Karen Len
dc.contributor.authorSaleheen, Danishen
dc.contributor.authorLee, Jong-Youngen
dc.contributor.authorElliott, Paulen
dc.contributor.authorGierman, Hinco Jen
dc.contributor.authorWiller, Cristen Jen
dc.contributor.authorFranke, Ludeen
dc.contributor.authorHovingh, G Keesen
dc.contributor.authorTaylor, Kent Den
dc.contributor.authorDedoussis, Georgeen
dc.contributor.authorSever, Peteren
dc.contributor.authorWong, Andrewen
dc.contributor.authorLind, Larsen
dc.contributor.authorAssimes, Themistocles Len
dc.contributor.authorNjølstad, Ingeren
dc.contributor.authorSchwarz, Peter Ehen
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorSnieder, Harolden
dc.contributor.authorCaulfield, Mark Jen
dc.contributor.authorMelander, Olleen
dc.contributor.authorLaakso, Markkuen
dc.contributor.authorSaltevo, Juhaen
dc.contributor.authorRauramaa, Raineren
dc.contributor.authorTuomilehto, Jaakkoen
dc.contributor.authorIngelsson, Eriken
dc.contributor.authorLehtimäki, Terhoen
dc.contributor.authorHveem, Kristianen
dc.contributor.authorPalmas, Walteren
dc.contributor.authorMärz, Winfrieden
dc.contributor.authorKumari, Meenaen
dc.contributor.authorSalomaa, Veikkoen
dc.contributor.authorChen, Yii-Der Ien
dc.contributor.authorRotter, Jerome Ien
dc.contributor.authorFroguel, Philippeen
dc.contributor.authorJarvelin, Marjo-Riittaen
dc.contributor.authorLakatta, Edward Gen
dc.contributor.authorKuulasmaa, Karien
dc.contributor.authorFranks, Paul Wen
dc.contributor.authorHamsten, Andersen
dc.contributor.authorWichmann, H-Erichen
dc.contributor.authorPalmer, Colin NAen
dc.contributor.authorStefansson, Karien
dc.contributor.authorRidker, Paul Men
dc.contributor.authorLoos, Ruth JFen
dc.contributor.authorChakravarti, Aravindaen
dc.contributor.authorDeloukas, Panosen
dc.contributor.authorMorris, Andrew Pen
dc.contributor.authorNewton-Cheh, Christopheren
dc.contributor.authorMunroe, Patricia Ben
dc.date.accessioned2017-11-20T12:53:53Z
dc.date.available2017-11-20T12:53:53Z
dc.date.issued2016-10-01en
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/269426
dc.description.abstractTo dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
dc.languageengen
dc.titleThe genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.en
dc.typeArticle
prism.issueIdentifier10en
prism.publicationDate2016en
prism.publicationNameNat Geneten
prism.volume48en
dc.identifier.doi10.17863/CAM.15649
dcterms.dateAccepted2016-08-15en
rioxxterms.versionofrecord10.1038/ng.3667en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-10-01en
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidBarroso, Ines [0000-0001-5800-4520]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidMarkus, Hugh [0000-0002-9794-5996]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidStirrups, Kathleen [0000-0002-6823-3252]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (MR/P02811X/1)
pubs.funder-project-idEuropean Commission and European Federation of Pharmaceutical Industries and Associations (EFPIA) FP7 Innovative Medicines Initiative (IMI) (116074)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idMRC (MR/P013880/1)
pubs.funder-project-idUme� University (unknown)
pubs.funder-project-idNHS Blood and Transplant (NHSBT) (WP12-01)
pubs.funder-project-idEC FP7 CP (279143)
pubs.funder-project-idNHS Blood and Transplant (NHSBT) (11-01-GEN)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idEuropean Commission (279233)
pubs.funder-project-idEuropean Research Council (268834)
pubs.funder-project-idMRC (MR/J015709/1)
pubs.funder-project-idMRC (MR/J006602/1)
pubs.funder-project-idMRC (MR/J006599/1)
pubs.funder-project-idMRC (via University of Leicester) (MR/M012816/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idBritish Heart Foundation (RG/16/4/32218)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (3819-1617-25)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10024)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (3819-1516-29)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idNational Institute of Neurological Disorders and Stroke (NINDS) (R21NS064908)
pubs.funder-project-idNational Heart Lung and Blood Institute (RC2HL101834)
pubs.funder-project-idFogarty International Center (RC1TW008485)
pubs.funder-project-idMedical Research Council (MC_U106179472)
cam.issuedOnline2016-09-12en


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