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Extensive migration of young neurons into the infant human frontal lobe.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Paredes, Mercedes F 
James, David 
Gil-Perotin, Sara 
Kim, Hosung 
Cotter, Jennifer A 

Abstract

The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in size and complexity relative to other species, but the processes that have contributed to this expansion are unknown. Our studies of postmortem infant human brains revealed a collection of neurons that migrate and integrate widely into the frontal lobe during infancy. Chains of young neurons move tangentially close to the walls of the lateral ventricles and along blood vessels. These cells then individually disperse long distances to reach cortical tissue, where they differentiate and contribute to inhibitory circuits. Late-arriving interneurons could contribute to developmental plasticity, and the disruption of their postnatal migration or differentiation may underlie neurodevelopmental disorders.

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Keywords

Cell Movement, Doublecortin Domain Proteins, Frontal Lobe, Gyrus Cinguli, Humans, Infant, Interneurons, Lateral Ventricles, Microtubule-Associated Proteins, Neurogenesis, Neuronal Plasticity, Neurons, Neuropeptides

Journal Title

Science

Conference Name

Journal ISSN

0036-8075
1095-9203

Volume Title

354

Publisher

American Association for the Advancement of Science (AAAS)