Terminating the replication helicase.
Nature cell biology
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Gaggioli, V., & Zegerman, P. (2017). Terminating the replication helicase.. Nature cell biology, 19 (5), 410-412. https://doi.org/10.1038/ncb3519
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.
DNA Helicases, Cell Cycle Proteins, Ubiquitin, DNA Replication, Adenosine Triphosphatases
Worldwide Cancer Research (formerly AICR) (10-0908)
WELLCOME TRUST (107056/Z/15/Z)
External DOI: https://doi.org/10.1038/ncb3519
This record's URL: https://www.repository.cam.ac.uk/handle/1810/269552