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dc.contributor.authorValcarcel-Jimenez, Len
dc.contributor.authorGaude, EGen
dc.contributor.authorTorrano, Ven
dc.contributor.authorFrezza, Christianen
dc.contributor.authorCarracedo, Aen
dc.date.accessioned2017-11-24T16:46:50Z
dc.date.available2017-11-24T16:46:50Z
dc.date.issued2017-10-01en
dc.identifier.issn1043-2760
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/269695
dc.description.abstractAltered metabolism is a distinct feature of cancer cells. During transformation, the entire metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst the molecular underpinnings of this metabolic reprogramming have been described, its role in tumor progression is still under investigation. Importantly, the mitochondrion is a central actor in many of the metabolic processes that are altered in tumors. Yet, we have only begun to understand the dualities of mitochondrial function during cancer metastasis and therapy resistance. Paradoxically, mitochondrial metabolism can be both advantageous and detrimental to these processes, highlighting the need for a better understanding of the molecular and microenvironmental cues that define the role of this fascinating organelle. In this review article, we present an updated view on the different mitochondrial metabolic strategies adopted by cancer cells to overcome the many hurdles faced during tumor progression.
dc.description.sponsorshipThe work of A.C. is supported by the Ramón y Cajal award, the Basque Department of Industry, Tourism and Trade (Etortek) and the Department of Education (IKERTALDE IT1106-16), ISCIII (PI10/01484, PI13/00031), FERO VIII Fellowship, the BBVA Foundation, the MINECO (SAF2016-79381-R), and the European Research Council Starting Grant (336343). The participation of A.C. and V.T. as part of CIBERONC was cofunded with FEDER funds. L.V-J. is supported by Basque Government of Education. V.T. is funded by Fundación Vasca de Innovación e Investigación Sanitarias, BIOEF (BIO15/CA/052), the AECC J.P. Bizkaia, and the Basque Department of Health (2016111109). E.G. and C.F. are supported by the Medical Research Council, core fund to the MRC Cancer Unit SKAG106.
dc.publisherElsevier
dc.titleMitochondrial metabolism: Yin and Yang for tumor progressionen
dc.typeArticle
prism.endingPage757
prism.issueIdentifier10en
prism.publicationDate2017en
prism.publicationNameTrends in Endocrinology and Metabolismen
prism.startingPage748
prism.volume28en
dc.identifier.doi10.17863/CAM.10798
dcterms.dateAccepted2017-06-20en
rioxxterms.versionofrecord10.1016/j.tem.2017.06.004en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-10-01en
dc.contributor.orcidFrezza, Christian [0000-0002-3293-7397]
dc.identifier.eissn1879-3061
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12022/1_do not transfer?)
pubs.funder-project-idMedical Research Council (MC_UU_12022/6)
cam.issuedOnline2017-09-19en
rioxxterms.freetoread.startdate2018-09-19


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