Equine renal hemangiosarcoma: clinical presentation, pathologic features, and pSTAT3 expression
Spanner Kristiansen, J
Journal of Veterinary Diagnostic Investigation
American Association of Veterinary Laboratory Diagnosticians
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Hughes, K., Scott, V., Blanck, M., Barnett, T., Spanner Kristiansen, J., & Foote, A. (2018). Equine renal hemangiosarcoma: clinical presentation, pathologic features, and pSTAT3 expression. Journal of Veterinary Diagnostic Investigation https://doi.org/10.1177/1040638717745575
Hemangiosarcoma is an uncommon tumor in horses. We characterized 3 cases of equine renal hemangiosarcoma, focusing on clinical and pathologic features, and describe occurrence of the epithelioid variant of hemangiosarcoma in one of these cases. Nuclear expression of phosphorylated STAT3 (pSTAT3), was assessed to analyze potential inappropriate STAT3 activation as a component of tumor pathogenesis. Clinical signs in the 3 horses included insidious weight loss, followed in one case by serosanguineous nasal discharge and terminal epistaxis, and non-specific signs of abdominal pain. Two of the hemangiosarcomas had a classical histopathologic appearance; in the other, neoplastic cells were polygonal and arranged in densely packed sheets, resembling the epithelioid variant. Cross reactivity of a pSTAT3 antibody was established by demonstration of pSTAT3 expression in the epithelium of glabrous skin by immunoblotting and immunohistochemistry. In the epithelioid hemangiosarcoma, ~ 40% of neoplastic cells exhibited nuclear pSTAT3 expression, but in the other 2 cases, expression was weak and variable in the neoplastic population, although stromal cell pSTAT3 activity was evident in pulmonary metastases in one case.
Epithelioid, Hemangiosarcoma, Horse, Kidney, Renal, Skin, STAT3
Zoetis Clinical Research Prize awarded to KH. Publication costs were supported by Girton College Cambridge.
External DOI: https://doi.org/10.1177/1040638717745575
This record's URL: https://www.repository.cam.ac.uk/handle/1810/269898