Case Report: Extreme Levels of Serum S-100B in a Patient with Chronic Subdural Hematoma.
Published version
Peer-reviewed
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Authors
Persson, Malin Elisabet
Thelin, Eric Peter
Bellander, Bo-Michael
Abstract
The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentleman with a chronic subdural hemorrhage, serum S-100B levels of 22 μg/l, and a history of malignant melanoma. Both intra- and extra-cranial sources of S-100B are evaluated and imply an unclear contribution of several sources to the total serum concentration. Potential sources of error when interpreting serum concentrations of S-100B are discussed.
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Keywords
S-100B, biomarkers, human, malignant melanoma, neurosurgery
Journal Title
Front Neurol
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Journal ISSN
1664-2295
1664-2295
1664-2295
Volume Title
3
Publisher
Frontiers Media SA