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dc.contributor.authorReigh, Shang-Yiken
dc.contributor.authorLauga, Eric Laugaen
dc.date.accessioned2017-12-05T17:52:44Z
dc.date.available2017-12-05T17:52:44Z
dc.date.issued2017-09-01en
dc.identifier.issn2469-990X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/269964
dc.description.abstractThe bacterium Helicobacter pylori causes ulcers in the stomach of humans by invading mucus layers protecting epithelial cells. It does so by chemically changing the rheological properties of the mucus from a high-viscosity gel to a low-viscosity solution in which it may self-propel. We develop a two-fluid model for this process of swimming under self-generated confinement. We solve exactly for the flow and the locomotion speed of a spherical swimmer located in a spherically symmetric system of two Newtonian fluids whose boundary moves with the swimmer. We also treat separately the special case of an immobile outer fluid. In all cases, we characterize the flow fields, their spatial decay, and the impact of both the viscosity ratio and the degree of confinement on the locomotion speed of the model swimmer. The spatial decay of the flow retains the same power-law decay as for locomotion in a single fluid but with a decreased magnitude. Independent of the assumption chosen to characterize the impact of confinement on the actuation applied by the swimmer, its locomotion speed always decreases with an increase in the degree of confinement. Our modeling results suggest that a low-viscosity region of at least six times the effective swimmer size is required to lead to swimming with speeds similar to locomotion in an infinite fluid, corresponding to a region of size above ≈25μm for Helicobacter pylori.
dc.description.sponsorshipThis work was funded in part by the Isaac Newton Trust, Cambridge, and by the European Union through a Marie Curie CIG Grant and a ERC Consolidator Grant.
dc.languageengen
dc.publisherAmerican Physical Society
dc.titleA two-fluid model for locomotion under self-confinementen
dc.typeArticle
prism.number093101en
prism.publicationDate2017en
prism.publicationNamePhysical Review Fluidsen
prism.volume2en
dc.identifier.doi10.17863/CAM.12151
dcterms.dateAccepted2017-07-25en
rioxxterms.versionofrecord10.1103/PhysRevFluids.2.093101en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-09-01en
dc.contributor.orcidLauga, Eric Lauga [0000-0002-8916-2545]
dc.identifier.eissn2469-990X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Commission (618323)
pubs.funder-project-idECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (682754)
cam.issuedOnline2017-09-07en
rioxxterms.freetoread.startdate2018-09-07


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