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dc.contributor.authorKnott, Craigen
dc.contributor.authorBell, Stevenen
dc.contributor.authorBritton, Annieen
dc.date.accessioned2017-12-05T18:38:01Z
dc.date.available2017-12-05T18:38:01Z
dc.date.issued2018-01en
dc.identifier.issn0965-2140
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/269969
dc.description.abstractBackground and aims Studies that report the relationship between alcohol consumption and disease risk have predominantly operationalised drinking according to a single baseline measure. The resulting assumption of longitudinal stability may be simplistic and complicate interpretation of risk estimates. This study aims to describe changes to the volume of consumption across the adult life course according to baseline categories of drinking. Design A prospective observational study. Setting United Kingdom. Participants A cohort of British civil servants totalling 6,838 men and 3,372 women aged 34-55 years at baseline, followed for a mean 19.1 (SD 9.5) years. Measurements The volume of weekly alcohol consumption was estimated from data concerning the frequency and number of drinks consumed. Baseline categories were defined: non-current drinkers, infrequent drinkers, 0.1-50.0 g/week, 50.1-100.0 g/week, 100.1-150.0 g/week and 150.1-250.0 g/week, and >250.0 g/week. For women, the highest category was defined as >100.0 g/week. Baseline frequency was derived as ‘daily or almost daily’ and ‘not daily or almost daily’. Trajectories were estimated within baseline categories using growth curve models. Findings Trajectories differed between men and women, but were relatively stable within light-to-moderate categories of baseline consumption. Drinking was least stable within the highest categories of baseline consumption (men: >250.0 g/week; women: >100.0 g/week), declining by 47.0 (95% CI [40.7, 53.2]) and 16.8 g/week (95% CI [12.6, 21.0]) respectively per 10-year increase in age. These declines were not a consequence of sudden transitions to complete abstention. Rates of decline appear greatest in older age, with trajectories converging toward moderate volumes. Conclusion Among UK civil servants, consumption within baseline drinking categories is generally stable across the life course, except among heavier baseline drinkers, for whom intakes decline with increasing age. This shift does not appear to be driven by transitions to non-drinking. Cohorts of older people may be at particular risk of misclassifying former heavy drinkers as moderate consumers of alcohol.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.subjectHumansen
dc.subjectCohort Studiesen
dc.subjectLongitudinal Studiesen
dc.subjectProspective Studiesen
dc.subjectAlcohol Drinkingen
dc.subjectSex Factorsen
dc.subjectAdulten
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectUnited Kingdomen
dc.titleThe stability of baseline-defined categories of alcohol consumption during the adult life-course: a 28-year prospective cohort study.en
dc.typeArticle
prism.endingPage43
prism.issueIdentifier1en
prism.publicationDate2018en
prism.publicationNameAddiction (Abingdon, England)en
prism.startingPage34
prism.volume113en
dc.identifier.doi10.17863/CAM.12167
dcterms.dateAccepted2017-07-14en
rioxxterms.versionofrecord10.1111/add.13949en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidKnott, Craig [0000-0002-8593-6216]
dc.contributor.orcidBell, Steven [0000-0001-6774-3149]
dc.contributor.orcidBritton, Annie [0000-0002-6412-5430]
dc.identifier.eissn1360-0443
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
rioxxterms.freetoread.startdate2018-07-22


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