The Late Pleistocene is a key period to understand the shift from the Middle (MSA) to the Late Stone Age (LSA) in Africa. More generally, it is also a crucial time for elucidation of changes in the technological behaviours of human populations in Africa after the main Out of Africa event of modern humans ca. 60-50 thousand years ago. However, the archaeological record for this period is relatively poor, particularly for the Horn of Africa. Here we present a detailed analysis of the lithic assemblages from Goda Buticha (GB), a cave in southeastern Ethiopia, which has yielded a long stratigraphic sequence including Late Pleistocene and Holocene levels. This study (1) contributes to a better knowledge of the late MSA in the Horn of Africa; (2) documents a late Holocene LSA level (GB – Complex I); (3) highlights the presence of MSA characteristics associated with LSA features in the Holocene (GB – Layer IIc). This adds to the emerging record of great lithic technological variability during the Late Pleistocene and Holocene in this region.