Show simple item record

dc.contributor.authorMarkl, Danielen
dc.contributor.authorYassin, Samyen
dc.contributor.authorWilson, Ianen
dc.contributor.authorGoodwin, Daniel Jen
dc.contributor.authorAnderson, Andrewen
dc.contributor.authorZeitler, Axelen
dc.date.accessioned2017-12-08T17:25:19Z
dc.date.available2017-12-08T17:25:19Z
dc.date.issued2017-06-30en
dc.identifier.issn0378-5173
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270110
dc.description.abstractOral dosage forms are an integral part of modern health care and account for the majority of drug delivery systems. Traditionally the analysis of the dissolution behaviour of a dosage form is used as the key parameter to assess the performance of a drug product. However, understanding the mechanisms of disintegration is of critical importance to improve the quality of drug delivery systems. The disintegration performance is primarily impacted by the hydration and subsequent swelling of the powder compact. Here we compare liquid ingress and swelling data obtained using terahertz pulsed imaging (TPI) to a set of mathematical models. The interlink between hydration kinetics and swelling is described by a model based on Darcy's law and a modified swelling model based on that of Schott. Our new model includes the evolution of porosity, pore size and permeability as a function of hydration time. Results obtained from two sets of samples prepared from pure micro-crystalline cellulose (MCC) indicate a clear difference in hydration and swelling for samples of different porosities and particle sizes, which are captured by the model. Coupling a novel imaging technique, such as TPI, and mathematical models allows better understanding of hydration and swelling and eventually tablet disintegration.
dc.description.sponsorshipD.M. and J.A.Z. would like to acknowledge the U.K. Engineering and Physical Sciences Research Council (EPSRC) for funding (EP/L019922/1). S.Y. would like to thank the EPSRC for a studentship.
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPowder compactsen
dc.subjectTablet disintegrationen
dc.subjectTerahertz pulsed imagingen
dc.subjectLiquid penetrationen
dc.subjectSwellingen
dc.subjectPorosityen
dc.titleMathematical modelling of liquid transport in swelling pharmaceutical immediate release tabletsen
dc.typeArticle
prism.endingPage10
prism.issueIdentifier1-2en
prism.publicationDate2017en
prism.publicationNameInternational Journal of Pharmaceuticsen
prism.startingPage1
prism.volume526en
dc.identifier.doi10.17863/CAM.16925
dcterms.dateAccepted2017-04-06en
rioxxterms.versionofrecord10.1016/j.ijpharm.2017.04.015en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-06-30en
dc.contributor.orcidMarkl, Daniel [0000-0003-0411-733X]
dc.contributor.orcidWilson, Ian [0000-0003-3950-9165]
dc.contributor.orcidZeitler, Axel [0000-0002-4958-0582]
dc.identifier.eissn1873-3476
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/L019922/1)
cam.issuedOnline2017-04-08en
datacite.issupplementedby.doi10.17863/CAM.9101en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International