Show simple item record

dc.contributor.authorAjithkumar, Thankamma
dc.contributor.authorPrice, Stephen
dc.contributor.authorHoran, Gail
dc.contributor.authorBurke, Amos
dc.contributor.authorJefferies, Sarah
dc.date.accessioned2017-12-12T16:00:43Z
dc.date.available2017-12-12T16:00:43Z
dc.date.issued2017-02
dc.identifier.issn1470-2045
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270163
dc.description.abstractNeurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of the main contributors to neurocognitive sequelae. Current approaches for prevention and reduction of neurocognitive dysfunction include avoidance of radiotherapy in young children and reduction of the radiotherapy dose and volume of brain irradiated. Substantial advances have been made in brain imaging, especially with functional imaging and fibre tracking with the use of diffusion tensor imaging. Radiotherapy techniques for photon therapy have also evolved, with widespread use of techniques such as image-guided radiotherapy, volumetric modulated arc therapy, helical tomotherapy, and adaptive radiotherapy. The number of proton beam and heavy ion therapy facilities is increasing worldwide and there is great enthusiasm for clinical use of advanced MRI-guided radiotherapy systems. Here, we review the potential role of modern imaging and innovative radiotherapy techniques in minimisation of neurocognitive sequelae in children with brain tumours, and discuss various strategies to integrate these advances to drive further research.
dc.format.mediumPrint
dc.languageeng
dc.publisherElsevier BV
dc.subjectHumans
dc.subjectBrain Neoplasms
dc.subjectCognition Disorders
dc.subjectQuality of Life
dc.subjectChild
dc.subjectSurvivors
dc.subjectRadiotherapy, Intensity-Modulated
dc.subjectDiffusion Tensor Imaging
dc.titlePrevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours: the potential role of modern imaging and radiotherapy techniques.
dc.typeArticle
prism.endingPagee100
prism.issueIdentifier2
prism.publicationDate2017
prism.publicationNameLancet Oncol
prism.startingPagee91
prism.volume18
dc.identifier.doi10.17863/CAM.16997
dcterms.dateAccepted2016-10-26
rioxxterms.versionofrecord10.1016/S1470-2045(17)30030-X
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-02
dc.contributor.orcidPrice, Stephen [0000-0002-7535-3009]
dc.identifier.eissn1474-5488
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2018-02-02


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record