Show simple item record

dc.contributor.authorSun, Qianen
dc.contributor.authorGao, Huien
dc.contributor.authorSukhorukov, Gleb Ben
dc.contributor.authorRouth, Alexen
dc.date.accessioned2017-12-13T15:33:51Z
dc.date.available2017-12-13T15:33:51Z
dc.date.issued2017-09-18en
dc.identifier.issn1944-8244
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270207
dc.description.abstractSmall drug molecules are widely developed and used in the pharmaceutical industry. In the past few years, loading and delivering such molecules using polymer shell colloidosomes has attracted interest. Traditional polymer capsules fail to encapsulate low molecular weight materials for long times, since they are inherently porous and permeable for small molecules. In this paper, we report a method for encapsulating an anticancer drug with small molecule weight, for cell viability tests. The silver coated colloidosomes are prepared by making an aqueous core capsule with a polymer shell and then adding AgNO3, surfactant and L-ascorbic acid to form a second shell. The capsules are impermeable and can be triggered using ultrasound. We propose to use the capsules as drug carriers. The silver demonstrates a low cytotoxicity for up to ten capsules/cell. After triggering the silver shells by ultrasound, the released doxorubicin, the broken silver fragments, and the doxorubicin loading on the capsule surface all kill cells. The results demonstrate a non-permeable silver shell microcapsule with ultrasound sensitivity for potential medical applications.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherAmerican Chemical Society
dc.subjectSilveren
dc.subjectDoxorubicinen
dc.subjectAntineoplastic Agentsen
dc.subjectCapsulesen
dc.subjectDrug Carriersen
dc.titleSilver-Coated Colloidosomes as Carriers for an Anticancer Drug.en
dc.typeArticle
prism.endingPage32606
prism.issueIdentifier38en
prism.publicationDate2017en
prism.publicationNameACS applied materials & interfacesen
prism.startingPage32599
prism.volume9en
dc.identifier.doi10.17863/CAM.17048
dcterms.dateAccepted2017-09-07en
rioxxterms.versionofrecord10.1021/acsami.7b11128en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-09-18en
dc.contributor.orcidSun, Qian [0000-0002-5192-3599]
dc.contributor.orcidGao, Hui [0000-0001-9808-8343]
dc.contributor.orcidRouth, Alexander [0000-0002-3443-3053]
dc.identifier.eissn1944-8252
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2018-09-07


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record