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dc.contributor.authorBorakati, Aditya
dc.contributor.authorMafi, Reza
dc.contributor.authorMafi, Pouya
dc.contributor.authorKhan, Wasim S
dc.date.accessioned2017-12-13T16:03:56Z
dc.date.available2017-12-13T16:03:56Z
dc.date.issued2018-02-23
dc.identifier.issn1574-888X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270212
dc.description.abstractBACKGROUND: Osteoarthritis (OA) is a major global burden creating significant morbidity worldwide. Current curative therapies are expensive, challenging to access and have significant risks, making them infeasible and difficult in many cases. Mesenchymal stem cells (MSCs) can be applied to joints and may regenerate the cartilage damaged in OA, this therapy may be advantageous to existing treatments. OBJECTIVE: We systematically reviewed clinical trials of MSCs for cartilage repair and provide an overview of the literature in this area here. MEDLINE, Embase, CENTRAL, clinicaltrials.gov and Open- Grey were searched for controlled trials and case series with >5 patents involving MSC therapy for cartilage repair. The controlled trials were meta-analysed and the primary outcome measure was improvement in pain over the control group. A narrative synthesis was composed for the case series. RESULTS: A significant reduction in pain was found with the use of MSCs over controls: Standardised mean difference=-1.27 (95% Confidence intervals -1.95 to -0.58). However, the data was extremely heterogeneous with I2=95%, this may be attributed to differing therapies, clinical indication for treatment and joints treated amongst others. Case series showed improvements in treated patients with a variety of differing treatments and by many outcomes. There were no severe adverse outcomes found across all studies that could be attributed to MSCs, implying their safety. CONCLUSION: We conclude that MSCs have significant potential for the treatment of OA, however, larger, more consistent trials are needed for conclusive analysis.
dc.format.mediumPrint
dc.languageeng
dc.publisherBentham Science Publishers Ltd.
dc.subjectHumans
dc.subjectOsteoarthritis
dc.subjectTreatment Outcome
dc.subjectMesenchymal Stem Cell Transplantation
dc.subjectRegenerative Medicine
dc.subjectFemale
dc.subjectMale
dc.subjectClinical Trials as Topic
dc.titleA Systematic Review And Meta-Analysis of Clinical Trials of Mesenchymal Stem Cell Therapy for Cartilage Repair.
dc.typeArticle
prism.endingPage225
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameCurr Stem Cell Res Ther
prism.startingPage215
prism.volume13
dc.identifier.doi10.17863/CAM.17055
dcterms.dateAccepted2016-03-13
rioxxterms.versionofrecord10.2174/1574888X12666170915120620
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-02
dc.contributor.orcidKhan, Wasim [0000-0003-3106-5424]
dc.identifier.eissn2212-3946
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2018-12-13


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