Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.
View / Open Files
Authors
Bui, Hai
Menke, Aswin
Chen, Yu-Chia
Bai, Qing
Burke, Derek
McTighe, Aimee
de Jager, Sarah
Nuthall, Hugh
Kuo, Ming-Shang
Chacinska, Agnieszka
Burton, Edward A
O'Neill, Michael J
Publication Date
2015-12Journal Title
Human molecular genetics
ISSN
0964-6906
Volume
24
Issue
23
Pages
6640-6652
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Keatinge, M., Bui, H., Menke, A., Chen, Y., Sokol, A. M., Bai, Q., Ellett, F., et al. (2015). Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.. Human molecular genetics, 24 (23), 6640-6652. https://doi.org/10.1093/hmg/ddv369
Keywords
Microglia, Neurons, Animals, Zebrafish, Gaucher Disease, Disease Models, Animal, Glucosylceramidase, Zebrafish Proteins, MicroRNAs, Cell Death, Up-Regulation, Sequence Deletion, alpha-Synuclein
Identifiers
External DOI: https://doi.org/10.1093/hmg/ddv369
This record's URL: https://www.repository.cam.ac.uk/handle/1810/270371
Recommended or similar items
The following licence files are associated with this item: