Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

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Authors

  Keatinge, Marcus

Bui, Hai

Menke, Aswin

Chen, Yu-Chia

  Sokol, Anna M

Bai, Qing

  Ellett, Felix

  Da Costa, Marc

Burke, Derek

  Gegg, Matthew

  Trollope, Lisa

  Payne, Thomas

McTighe, Aimee

  Mortiboys, Heather

de Jager, Sarah

Nuthall, Hugh

Kuo, Ming-Shang

  Fleming, Angeleen

  Schapira, Anthony HV

  Renshaw, Stephen A

  Highley, J Robin

Chacinska, Agnieszka

  Panula, Pertti

Burton, Edward A

O'Neill, Michael J

  Bandmann, Oliver

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Publication Date

2015-12

Journal Title

Human molecular genetics

ISSN

0964-6906

Volume

24

Issue

23

Pages

6640-6652

Language

eng

Type

Article

This Version

VoR

Physical Medium

Print-Electronic

Metadata

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Citation

Keatinge, M., Bui, H., Menke, A., Chen, Y., Sokol, A. M., Bai, Q., Ellett, F., et al. (2015). Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.. Human molecular genetics, 24 (23), 6640-6652. https://doi.org/10.1093/hmg/ddv369

Keywords

Microglia, Neurons, Animals, Zebrafish, Gaucher Disease, Disease Models, Animal, Glucosylceramidase, Zebrafish Proteins, MicroRNAs, Cell Death, Up-Regulation, Sequence Deletion, alpha-Synuclein

Identifiers

External DOI: https://doi.org/10.1093/hmg/ddv369

This record's URL: https://www.repository.cam.ac.uk/handle/1810/270371



Rights

Attribution 4.0 International

Licence URL: http://creativecommons.org/licenses/by/4.0/