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dc.contributor.authorMackeith, Samuelen
dc.contributor.authorDas, Tilaken
dc.contributor.authorGraves, Martinen
dc.contributor.authorPatterson, Andrewen
dc.contributor.authorDonnelly, Neilen
dc.contributor.authorMannion, Richarden
dc.contributor.authorAxon, Patricken
dc.contributor.authorTysome, Jamesen
dc.date.accessioned2018-01-10T12:36:45Z
dc.date.available2018-01-10T12:36:45Z
dc.date.issued2018-04en
dc.identifier.issn0937-4477
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270461
dc.description.abstractObjective: Accurate and precise measurement of vestibular schwannoma (VS) size is key to clinical management decisions. Linear measurements are used in routine clinical practice but are prone to measurement error. This study aims to compare a semi-automated volume segmentation tool against standard linear method for measuring small VS. This study also examines whether oblique tumour orientation can contribute to linear measurement error. Study design: Experimental comparison of observer agreement using two measurement techniques. Setting: Tertiary skull base unit. Participants: 24 patients with unilateral sporadic small (<15mm maximum intracranial dimension) VS imaged with 1mm thickness T1-weighted Gadolinium enhanced MRI. Main outcome measures: 1 Intra and inter-observer intraclass correlation coefficients (ICC), repeatability coefficients (RC) and relative smallest detectable difference (%SDD). 2 Mean change in maximum linear dimension following reformatting to correct for oblique orientation of VS. Results: Intra-observer ICC was higher for semi-automated volumetric when compared with linear measurements, 0.998 (95% CI 0.994 – 0.999) vs 0.936 (95% CI 0.856 – 0.972), p<0.0001. Inter-observer ICC was also higher for volumetric vs linear measurements, 0.989 (95% CI 0.975 – 0.995) vs 0.946 (95% CI 0.880 – 0.976), p=0.0045. The intra-observer %SDD was similar for volumetric and linear measurements, 9.9% vs 11.8%. However, the inter-observer %SDD was greater for volumetric than linear measurements, 20.1% vs 10.6%. Following oblique reformatting to correct tumour angulation, the mean increase in size was 1.14mm (p=0.04). Conclusion: Semi-automated volumetric measurements are more repeatable than linear measurements when measuring small VS and should be considered for use in clinical practice. Oblique orientation of VS may contribute to linear measurement error.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectHumansen
dc.subjectNeuroma, Acousticen
dc.subjectCranial Nerve Neoplasmsen
dc.subjectVestibulocochlear Nerve Diseasesen
dc.subjectGadoliniumen
dc.subjectContrast Mediaen
dc.subjectObserver Variationen
dc.subjectMagnetic Resonance Imagingen
dc.subjectTumor Burdenen
dc.subjectReproducibility of Resultsen
dc.titleA comparison of semi-automated volumetric vs linear measurement of small vestibular schwannomas.en
dc.typeArticle
prism.endingPage874
prism.issueIdentifier4en
prism.publicationDate2018en
prism.publicationNameEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgeryen
prism.startingPage867
prism.volume275en
dc.identifier.doi10.17863/CAM.17203
dcterms.dateAccepted2018-01-03en
rioxxterms.versionofrecord10.1007/s00405-018-4865-zen
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-04en
dc.contributor.orcidMacKeith, Samuel [0000-0002-1499-649X]
dc.contributor.orcidDas, Tilak [0000-0003-0655-412X]
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.contributor.orcidPatterson, Andrew James [0000-0001-8338-5652]
dc.identifier.eissn1434-4726
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:59:36 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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