siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Jimenez-Sanchez, Maria; Lam, Wun; Hannus, Michael; Sönnichsen, Birte; Imarisio, Sara; Fleming, Angeleen; Tarditi, Alessia; Menzies, Fiona; Dami, Teresa Ed; Xu, Catherine; Gonzalez-Couto, Eduardo; Lazzeroni, Giulia; Heitz, Freddy; Diamanti, Daniela; Massai, Luisa; Satagopam, Venkata P; Marconi, Guido; Caramelli, Chiara; Nencini, Arianna; Andreini, Matteo; Sardone, Gian Luca; Caradonna, Nicola P; Porcari, Valentina; Scali, Carla; Schneider, Reinhard; Pollio, Giuseppe; O'Kane, Cahir; Caricasole, Andrea; Rubinsztein, David

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Authors

Jimenez-Sanchez, Maria

Lam, Wun

Hannus, Michael

Sönnichsen, Birte

Imarisio, Sara

Fleming, Angeleen

Tarditi, Alessia

Publication Date

2015-05

Journal Title

Nature chemical biology

ISSN

1552-4450

Volume

Issue

Pages

347-354

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Jimenez-Sanchez, M., Lam, W., Hannus, M., Sönnichsen, B., Imarisio, S., Fleming, A., Tarditi, A., et al. (2015). siRNA screen identifies QPCT as a druggable target for Huntington's disease.. Nature chemical biology, 11 (5), 347-354. https://doi.org/10.1038/nchembio.1790

Keywords

Neurons, Cells, Cultured, Animals, Mice, Inbred C57BL, Zebrafish, Humans, Mice, Drosophila, Huntington Disease, Aminoacyltransferases, alpha-Crystallin B Chain, Green Fluorescent Proteins, Nerve Tissue Proteins, RNA, Small Interfering, Enzyme Inhibitors, Drug Evaluation, Preclinical, Computational Biology, Mutation, Huntingtin Protein

Sponsorship

Wellcome Trust (095317/Z/11/Z)

MRC (MR/J006904/1)

Wellcome Trust (100140/Z/12/Z)

Wellcome Trust (095317/Z/11/A)

EC FP7 CP (305121)

Identifiers

External DOI: https://doi.org/10.1038/nchembio.1790

This record's URL: https://www.repository.cam.ac.uk/handle/1810/270483

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