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dc.contributor.authorCosta, ASHen
dc.contributor.authorFrezza, Christianen
dc.date.accessioned2018-01-11T13:08:39Z
dc.date.available2018-01-11T13:08:39Z
dc.date.issued2017-01en
dc.identifier.issn1937-6448
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270511
dc.description.abstractThe process of tumorigenesis can be described by a series of molecular features, among which alteration of cellular metabolism has recently emerged. This metabolic rewiring fulfills the energy and biosynthetic demands of fast proliferating cancer cells and amplifies their metabolic repertoire to survive and proliferate in the poorly oxygenated and nutrient-deprived tumor microenvironment. During the last decade, the complex reprogramming of cancer cell metabolism has been widely investigated, revealing cancer-specific metabolic alterations. These include dysregulation of glucose and glutamine metabolism, alterations of lipid synthesis and oxidation, and a complex rewiring of mitochondrial function. However, mitochondria are not the only metabolically active organelles within the cell, and other organelles, including lysosomes, peroxisomes, and endoplasmic reticulum, harbor components of the metabolic network. Of note, dysregulation of the function of these organelles is increasingly recognized in cancer cells. However, to what extent these organelles contribute to the metabolic reprogramming of cancer is not fully understood. In this review, we describe the main metabolic functions of these organelles and provide insights into how they communicate to orchestrate a coordinated metabolic reprogramming during transformation.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.subjectOrganellesen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectNeoplasmsen
dc.subjectCell Transformation, Neoplasticen
dc.subjectCell Compartmentationen
dc.subjectCarcinogenesisen
dc.titleMetabolic Reprogramming and Oncogenesis: One Hallmark, Many Organelles.en
dc.typeArticle
prism.endingPage231
prism.publicationDate2017en
prism.publicationNameInternational review of cell and molecular biologyen
prism.startingPage213
prism.volume332en
dc.identifier.doi10.17863/CAM.17405
dcterms.dateAccepted2017-01-21en
rioxxterms.versionofrecord10.1016/bs.ircmb.2017.01.001en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01en
dc.contributor.orcidCosta, ASH [0000-0001-8932-6370]
dc.contributor.orcidFrezza, Christian [0000-0002-3293-7397]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12022/1_do not transfer?)
pubs.funder-project-idMedical Research Council (MC_UU_12022/6)
rioxxterms.freetoread.startdate2018-03-15


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