Exploiting tumour addiction with a serine and glycine-free diet.
Cell death and differentiation
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Amelio, I., Melino, G., & Frezza, C. (2017). Exploiting tumour addiction with a serine and glycine-free diet.. Cell death and differentiation, 24 (8), 1311-1313. https://doi.org/10.1038/cdd.2017.83
Understanding cancer metabolism is key to unveil the Achilles’ heel of cancer cells and provide novel therapeutic interventions for patients. While the rerouting of metabolic pathways during development1 or cancer transformation and progression2, 3, 4 has been extensively characterised, the exact dynamic of these events, their distribution and frequency in the different tumour types, and the correlation with genetic background remain largely unknown. In a recent article published in Nature, Karen Vousden’s team assesses the effect of serine and glycine dietary restriction in autochthonous mouse tumour models driven by different oncogenes (Maddocks et al, 2017)5, leading to potential area of therapeutic intervention.
Humans, Neoplasms, Serine, Glycine, Diet
MRC (MC_UU_12022/1_do not transfer?)
Medical Research Council (MC_UU_12022/6)
External DOI: https://doi.org/10.1038/cdd.2017.83
This record's URL: https://www.repository.cam.ac.uk/handle/1810/270512
Attribution-NonCommercial-ShareAlike 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-sa/4.0/
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