Bi-exponential 23 Na T2 * component analysis in the human brain.
Solanky, Bhavana S
Wheeler-Kingshott, Claudia AM
NMR in biomedicine
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Riemer, F., Solanky, B. S., Wheeler-Kingshott, C. A., & Golay, X. (2018). Bi-exponential 23 Na T2 * component analysis in the human brain.. NMR in biomedicine, 31 (5), e3899. https://doi.org/10.1002/nbm.3899
Purpose: To measure the sodium transverse relaxation time T2* in the healthy human brain. Methods: 5 healthy subjects were scanned with 18 echo times as short as 0.17 ms. T2*s were fitted on a voxel-by-voxel basis using a bi-exponential model. Data was also analysed using a continuous distribution fit with a region-of-interest based inverse Laplace transform. Results: Average T2* values were 3.4 ± 0.2 ms and 23.5 ± 1.8 ms in white matter (WM), for the short and long components respectively, as well as 3.9 ± 0.5 ms and 26.3 ± 2.6 ms for the short and long components respectively in grey matter (GM) using the bi-exponential model. Continuous distribution fits yielded results of 3.1 ± 0.3 ms and 18.8 ± 3.2 ms in WM, for the short and long components respectively, as well as 2.9 ± 0.4 ms and 17.2 ± 2 ms for the short and long components respectively in GM. Conclusion: 23Na T2* values of the brain for the short and long component for various anatomical locations using ultra-short echo times are presented for the first time.
Brain, Humans, Sodium, Magnetic Resonance Imaging, Phantoms, Imaging, Signal Processing, Computer-Assisted, Adult, Female, Male, White Matter, Gray Matter
This research was funded by the Multiple Sclerosis Society of Great Britain and Northern Ireland, the Medical Research Council and was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
External DOI: https://doi.org/10.1002/nbm.3899
This record's URL: https://www.repository.cam.ac.uk/handle/1810/270567