Robust modulation of integrate-and-fire models
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Van Pottelbergh, T., Drion, G., & Sepulchre, R. Robust modulation of integrate-and-fire models. Neural Computation https://doi.org/10.17863/CAM.17510
By controlling the state of neuronal populations, neuromodulators ultimately affect behaviour. A key neuromodulation mechanism is the alteration of neu- ronal excitability via the modulation of ion channel expression. This type of neuromodulation is normally studied via conductance-based models, but those models are computationally challenging for large-scale network sim- ulations needed in population studies. This paper studies the modulation properties of the Multi-Quadratic Integrate-and-Fire (MQIF) model, a gen- eralisation of the classical Quadratic Integrate-and-Fire (QIF) model. The model is shown to combine the computational economy of integrate-and-fire modelling and the physiological interpretability of conductance-based mod- elling. It is therefore a good candidate for affordable computational studies of neuromodulation in large networks.
modulation, integrate-and-fire models, single neuron dynamics
ECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (670645)
This record's DOI: https://doi.org/10.17863/CAM.17510
This record's URL: https://www.repository.cam.ac.uk/handle/1810/270592