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dc.contributor.authorSanchez, Diego H
dc.contributor.authorGaubert, Hervé
dc.contributor.authorDrost, Hajk-Georg
dc.contributor.authorZabet, Nicolae Radu
dc.contributor.authorPaszkowski, Jerzy
dc.date.accessioned2018-01-16T14:59:16Z
dc.date.available2018-01-16T14:59:16Z
dc.date.issued2017-11-03
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270640
dc.description.abstractRetrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical LTRs. This way, retrotransposons are divided into young, potentially mobile elements, and old that moved thousands or even millions of years ago. Both types are found within a single retrotransposon family and it is assumed that the old members will remain immobile and degenerate further. Here, we provide evidence in Arabidopsis that old members enter into replication/transposition cycles through high rates of intra-family recombination. The recombination occurs pairwise, resembling the formation of recombinant retroviruses. Thus, each transposition burst generates a novel progeny population of chromosomally integrated LTR retrotransposons consisting of pairwise recombination products produced in a process comparable the sexual exchange of genetic information. Our observations provide an explanation for the reported high rates of sequence diversification in retrotransposons.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectArabidopsis
dc.subjectDNA, Plant
dc.subjectRetroelements
dc.subjectSequence Analysis, DNA
dc.subjectRecombination, Genetic
dc.subjectTerminal Repeat Sequences
dc.subjectMutation
dc.subjectGenome, Plant
dc.subjectGenetic Variation
dc.subjectHigh-Throughput Nucleotide Sequencing
dc.subjectEcotype
dc.titleHigh-frequency recombination between members of an LTR retrotransposon family during transposition bursts.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2017
prism.publicationNameNat Commun
prism.startingPage1283
prism.volume8
dc.identifier.doi10.17863/CAM.17570
dcterms.dateAccepted2017-09-14
rioxxterms.versionofrecord10.1038/s41467-017-01374-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-11-03
dc.contributor.orcidDrost, Hajk-Georg [0000-0002-1567-306X]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (322621)
pubs.funder-project-idGatsby Charitable Foundation (unknown)
cam.issuedOnline2017-11-03
cam.orpheus.successThu Jan 30 13:00:45 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International