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dc.contributor.authorSanchez, Diego Hen
dc.contributor.authorGaubert, Hervéen
dc.contributor.authorDrost, Hajk-Georgen
dc.contributor.authorZabet, Nicolae Raduen
dc.contributor.authorPaszkowski, Jerzyen
dc.date.accessioned2018-01-16T14:59:16Z
dc.date.available2018-01-16T14:59:16Z
dc.date.issued2017-11-03en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/270640
dc.description.abstractRetrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical LTRs. This way, retrotransposons are divided into young, potentially mobile elements and old that moved thousands or even millions of years ago. Both types are found within a single retrotransposon family and it is assumed that the old members will remain immobile and degenerate further. Here, we provide evidence in Arabidopsis that old members enter into replication/transposition cycles through high rates of intra-family recombination. The recombination occurs pairwise, resembling the formation of recombinant retroviruses. Thus, each transposition burst generates a novel progeny population of chromosomally integrated LTR retrotransposons consisting of pairwise recombination products produced in a process comparable the sexual exchange of genetic information. Our observations provide an explanation for the reported high rates of sequence diversification in etrotransposons.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectArabidopsisen
dc.subjectDNA, Planten
dc.subjectRetroelementsen
dc.subjectSequence Analysis, DNAen
dc.subjectRecombination, Geneticen
dc.subjectTerminal Repeat Sequencesen
dc.subjectMutationen
dc.subjectGenome, Planten
dc.subjectGenetic Variationen
dc.subjectHigh-Throughput Nucleotide Sequencingen
dc.subjectEcotypeen
dc.titleHigh-frequency recombination between members of an LTR retrotransposon family during transposition bursts.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2017en
prism.publicationNameNature communicationsen
prism.startingPage1283
prism.volume8en
dc.identifier.doi10.17863/CAM.17570
dcterms.dateAccepted2017-09-14en
rioxxterms.versionofrecord10.1038/s41467-017-01374-xen
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-11-03en
dc.contributor.orcidDrost, Hajk-Georg [0000-0002-1567-306X]
dc.contributor.orcidZabet, Nicolae Radu [0000-0001-9964-6271]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (322621)
pubs.funder-project-idGatsby Charitable Foundation (unknown)
cam.orpheus.successThu Jan 30 13:00:45 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International