Towards resolving the presynaptic NMDA receptor debate.
Current opinion in neurobiology
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Bouvier, G., Larsen, R. S., Rodríguez-Moreno, A., Paulsen, O., & Sjöström, P. J. (2018). Towards resolving the presynaptic NMDA receptor debate.. Current opinion in neurobiology, 51 1-7. https://doi.org/10.1016/j.conb.2017.12.020
In the classical view, postsynaptic NMDA receptors (NMDARs) trigger Hebbian plasticity via Ca2+ influx. However, unconventional presynaptic NMDARs (preNMDARs) which regulate both long-term and short-term plasticity at several synapse types have also been found. A lack of sufficiently specific experimental manipulations and a poor understanding of how preNMDARs signal have contributed to long-standing controversy surrounding these receptors. Although several prior studies linked preNMDARs to neocortical timing-dependent long-term depression (tLTD), a recent study argues that the NMDARs are actually postsynaptic and signal metabotropically, i.e. without Ca2+. Other recent work indicates that, whereas ionotropic preNMDARs signaling controls evoked release, spontaneous release is regulated by metabotropic NMDAR signaling. We argue that elucidating unconventional NMDAR signaling modes — both presynaptically and metabotropically — is key to resolving the preNMDAR debate.
Synapses, Animals, Receptors, N-Methyl-D-Aspartate, Receptors, Presynaptic, Neuronal Plasticity
External DOI: https://doi.org/10.1016/j.conb.2017.12.020
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271039