Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics.
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Authors
Andrade, Ingrid
Fetter, Richard D
Publication Date
2017-10-23Journal Title
Elife
ISSN
2050-084X
Publisher
eLife Sciences Publications, Ltd
Volume
6
Language
eng
Type
Article
This Version
AM
Physical Medium
Electronic
Metadata
Show full item recordCitation
Gerhard, S., Andrade, I., Fetter, R. D., Cardona, A., & Schneider-Mizell, C. M. (2017). Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics.. Elife, 6 https://doi.org/10.7554/eLife.29089
Abstract
During postembryonic development, the nervous system must adapt to a growing body. How changes in neuronal structure and connectivity contribute to the maintenance of appropriate circuit function remains unclear. Previously , we measured the cellular neuroanatomy underlying synaptic connectivity in Drosophila (Schneider-Mizell et al., 2016). Here, we examined how neuronal morphology and connectivity change between first instar and third instar larval stages using serial section electron microscopy. We reconstructed nociceptive circuits in a larva of each stage and found consistent topographically arranged connectivity between identified neurons. Five-fold increases in each size, number of terminal dendritic branches, and total number of synaptic inputs were accompanied by cell type-specific connectivity changes that preserved the fraction of total synaptic input associated with each pre-synaptic partner. We propose that precise patterns of structural growth act to conserve the computational function of a circuit, for example determining the location of a dangerous stimulus.
Keywords
Nervous System, Nerve Net, Animals, Drosophila, Larva, Connectome
Identifiers
External DOI: https://doi.org/10.7554/eLife.29089
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271135
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