Trunk neural crest origin of dermal denticles in a cartilaginous fish.
View / Open Files
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
MetadataShow full item record
Gillis, J., Alsema, E. C., & Criswell, K. (2017). Trunk neural crest origin of dermal denticles in a cartilaginous fish.. Proceedings of the National Academy of Sciences of the United States of America, 114 (50), 13200-13205. https://doi.org/10.1073/pnas.1713827114
Cartilaginous fishes (e.g. sharks and skates) possess a postcranial dermal skeleton consisting of tooth-like “denticles” embedded within their skin. As with teeth, the principal skeletal tissue of dermal denticles is dentine. In the head, cranial neural crest cells give rise to the dentine-producing cells (odontoblasts) of teeth. However, trunk neural crest cells are generally regarded as non-skeletogenic, and so the embryonic origin of trunk denticle odontoblasts remains unresolved. Here, we use expression of the transcription factor FoxD3 to pinpoint the specification and emigration of trunk neural crest cells in embryos of a cartilaginous fish, the little skate (Leucoraja erinacea). Using cell lineage tracing, we further demonstrate that trunk neural crest cells do, in fact, give rise to odontoblasts of trunk dermal denticles. These findings expand the repertoire of vertebrate trunk neural crest cell fates during normal development, highlight the likely primitive skeletogenic potential of this cell population, and point to a neural crest origin of dentine throughout the ancestral vertebrate dermal skeleton.
Odontoblasts, Neural Crest, Animals, Skates (Fish), Cell Lineage, Biological Evolution
This research was supported by a Royal Society University Research Fellowship [UF130182 to J.A.G.], and by a grant from the University of Cambridge Isaac Newton Trust [14.23z to J.A.G.]. KEC was supported by a Royal Society Shooter International Postdoctoral Fellowship [NF160762].
Royal Society (uf130182)
Isaac Newton Trust (1423(z))
Royal Society (NF160762)
External DOI: https://doi.org/10.1073/pnas.1713827114
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271203