Advances in the generation of bioengineered bile ducts.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Justin, Alexander W
Saeb-Parsy, Kourosh https://orcid.org/0000-0002-0633-3696
Markaki, Athina E
Vallier, Ludovic https://orcid.org/0000-0002-3848-2602
Sampaziotis, Fotios https://orcid.org/0000-0003-0812-7586
Abstract
The generation of bioengineered biliary tissue could contribute to the management of some of the most impactful cholangiopathies associated with liver transplantation, such as biliary atresia or ischemic cholangiopathy. Recent advances in tissue engineering and in vitro cholangiocyte culture have made the achievement of this goal possible. Here we provide an overview of these developments and review the progress towards the generation and transplantation of bioengineered bile ducts. This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni and Peter Jansen.
Description
Keywords
Bile duct, Bioengineering, Cholangiopathy, Tissue engineering, Animals, Bile Duct Diseases, Bile Ducts, Bioartificial Organs, Biomedical Engineering, Cell Culture Techniques, Coculture Techniques, Disease Models, Animal, Epithelial Cells, Humans, Liver Transplantation, Organ Culture Techniques, Tissue Engineering
Journal Title
Biochim Biophys Acta Mol Basis Dis
Conference Name
Journal ISSN
0925-4439
1879-260X
1879-260X
Volume Title
1864
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (MR/L016761/1)
Medical Research Council (MC_PC_12009)
European Research Council (281335)
European Research Council (741707)
Medical Research Council (MC_PC_12009)
European Research Council (281335)
European Research Council (741707)
AWJ gratefully acknowledges support from EPSRC (EP/R511675/1). 18 LV has been supported by the ERC starting grant Relive-IMDs and the ERC advanced grant 19 New-Chol. FS gratefully acknowledges support by the Cambridge Biomedical Research 20 Centre, Addenbrooke’s Charitable Trust (ACT), Sparks and the Medical Research Council 21 (MRC).