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dc.contributor.authorLaurenti, Elisaen
dc.contributor.authorGottgens, Bertholden
dc.date.accessioned2018-01-30T17:24:31Z
dc.date.available2018-01-30T17:24:31Z
dc.date.issued2018-01-25en
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/271359
dc.description.abstractThe development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.
dc.description.sponsorshipE.L. is supported by a Sir Henry Dale fellowship from the Wellcome Trust (WT)/Royal Society. Research in the Laurenti and Gottgens laboratories is supported by the WT, CRUK, Bloodwise, MRC, BBSRC, NIH-NIDDK, and core support grants by the WT and MRC to the Wellcome-MRC Cambridge Stem Cell Institute.
dc.publisherSpringer Nature
dc.titleFrom haematopoietic stem cells to complex differentiation landscapesen
dc.typeArticle
prism.endingPage426
prism.publicationDate2018en
prism.publicationNameNatureen
prism.startingPage418
prism.volume553en
dc.identifier.doi10.17863/CAM.18341
dc.identifier.doi10.17863/CAM.18341
dcterms.dateAccepted2017-11-08en
rioxxterms.versionofrecord10.1038/nature25022en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01-25en
dc.contributor.orcidLaurenti, Elisa [0000-0002-9917-9092]
dc.contributor.orcidGottgens, Berthold [0000-0001-6302-5705]
dc.identifier.eissn1476-4687
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/P002293/1)
pubs.funder-project-idMRC (G0900951)
pubs.funder-project-idCancer Research UK (A8043)
pubs.funder-project-idIsaac Newton Trust (MINUTE 646(M))
pubs.funder-project-idLeukaemia & Lymphoma Research (7060)
pubs.funder-project-idLeukaemia & Lymphoma Research (8061)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M008975/1)
pubs.funder-project-idMRC (MC_PC_12009)
pubs.funder-project-idWELLCOME TRUST (107630/Z/15/Z)
pubs.funder-project-idNational Institutes of Health (NIH) (via Pennsylvania State University) (R24DK106766)
pubs.funder-project-idCancer Research UK (21762)
pubs.funder-project-idLeukaemia & Lymphoma Research (6072)
pubs.funder-project-idLeukaemia & Lymphoma Research (238)
pubs.funder-project-idLeukaemia & Lymphoma Research (12029)
cam.issuedOnline2018-01-24en
rioxxterms.freetoread.startdate2018-07-24


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