"Patient reported outcomes" following experimental surgery-using telemetry to assess movement in experimental ovine models.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
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Newell, K., Chitty, J., & Henson, F. (2018). "Patient reported outcomes" following experimental surgery-using telemetry to assess movement in experimental ovine models.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36 (5), 1498-1507. https://doi.org/10.1002/jor.23790
Many potential treatments for orthopaedic disease fail at the animal to human translational hurdle. One reason for this failure is that the majority of pre clinical outcome measurements emphasise structural changes, such as gross morphology and histology, and do not address pain or its alleviation, which is a key component of treatment success in man. With increasing emphasis on ‘patient reported outcome measurements (PROM)’ in clinical practice, in this study we have used two different telemetric methods (geolocation and Fitbark activity trackers) to measure movement behaviour, i.e. an indirect PROM, in an ovine osteoarthritis induction and an osteochondral defect model performed in adult female Welsh Mountain sheep. This study demonstrates that both systems can be used to track movement and activity of experimental sheep before and after surgery and that the Geolocator system recorded a decrease in distance moved and activity at the end of the experimental period in both models. The Fitbark activity tracker also recorded significant alterations in movement behaviour at the end of these studies and this method of recording showed a correlation between Fitbark data and radiography, macroscopic and histological scoring (well recognised outcome measurements), particularly in animals with large (10mm) defects i.e. more severe pathology. These results suggest that telemetry is able to track movement behaviour in experimental sheep and that the methodology should be considered for inclusion in outcome measures in preclinical orthopaedic research.
Animals, Sheep, Osteoarthritis, Disease Models, Animal, Telemetry, Movement, Female, Patient Reported Outcome Measures
ARTHRITIS RESEARCH UK (21161)
ARTHRITIS RESEARCH UK (21156)
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External DOI: https://doi.org/10.1002/jor.23790
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271412
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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