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dc.contributor.authorNewell, Karinen
dc.contributor.authorChitty, Joseen
dc.contributor.authorHenson, Francesen
dc.date.accessioned2018-01-31T15:53:45Z
dc.date.available2018-01-31T15:53:45Z
dc.date.issued2018-05en
dc.identifier.issn0736-0266
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/271412
dc.description.abstractMany potential treatments for orthopaedic disease fail at the animal to human translational hurdle. One reason for this failure is that the majority of pre clinical outcome measurements emphasise structural changes, such as gross morphology and histology, and do not address pain or its alleviation, which is a key component of treatment success in man. With increasing emphasis on ‘patient reported outcome measurements (PROM)’ in clinical practice, in this study we have used two different telemetric methods (geolocation and Fitbark activity trackers) to measure movement behaviour, i.e. an indirect PROM, in an ovine osteoarthritis induction and an osteochondral defect model performed in adult female Welsh Mountain sheep. This study demonstrates that both systems can be used to track movement and activity of experimental sheep before and after surgery and that the Geolocator system recorded a decrease in distance moved and activity at the end of the experimental period in both models. The Fitbark activity tracker also recorded significant alterations in movement behaviour at the end of these studies and this method of recording showed a correlation between Fitbark data and radiography, macroscopic and histological scoring (well recognised outcome measurements), particularly in animals with large (10mm) defects i.e. more severe pathology. These results suggest that telemetry is able to track movement behaviour in experimental sheep and that the methodology should be considered for inclusion in outcome measures in preclinical orthopaedic research.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAnimalsen
dc.subjectSheepen
dc.subjectOsteoarthritisen
dc.subjectDisease Models, Animalen
dc.subjectTelemetryen
dc.subjectMovementen
dc.subjectFemaleen
dc.subjectPatient Reported Outcome Measuresen
dc.title"Patient reported outcomes" following experimental surgery-using telemetry to assess movement in experimental ovine models.en
dc.typeArticle
prism.endingPage1507
prism.issueIdentifier5en
prism.publicationDate2018en
prism.publicationNameJournal of orthopaedic research : official publication of the Orthopaedic Research Societyen
prism.startingPage1498
prism.volume36en
dc.identifier.doi10.17863/CAM.18400
dcterms.dateAccepted2017-10-21en
rioxxterms.versionofrecord10.1002/jor.23790en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-05en
dc.contributor.orcidHenson, Frances [0000-0002-3518-1492]
dc.identifier.eissn1554-527X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idARTHRITIS RESEARCH UK (21161)
pubs.funder-project-idARTHRITIS RESEARCH UK (21156)
pubs.funder-project-idMRC (MR/L022893/1)
cam.orpheus.successThu Jan 30 13:00:37 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International