Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?
The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition
International Society for Magnetic Resonance in Medicine
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Riemer, F., McLean, M., Zaccagna, F., Grist, J., Schulte, R., Kaggie, J., Watts, C., et al. (2017). Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?. The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition. http://dev.ismrm.org/2017/2208.html
Incomplete fluid suppression on fluid-attenuated inversion-recovery 23Na-MRI (IR-23Na-MRI) was observed in three patients undergoing IR-23Na-MRI after gadolinium contrast injection, as part of a brain tumour imaging study. To evaluate this, 23Na-MRI T1 maps were acquired before and after injection of a gadolinium-based contrast agent on a grade IV glioma (GBM) patient, which showed a statistically significant change of 23Na-MRI T1 within the peritumoral oedema (p=0.0095). Gadolinium contrast-enhanced 23Na-MRI could potentially add further applications for sodium imaging and probe tumour tissue structure in new ways to investigate proliferation and treatment response.
Cancer Research UK (16465)
External link: http://dev.ismrm.org/2017/2208.html
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271562