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Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?

Accepted version
Peer-reviewed

Type

Conference Object

Change log

Authors

McLean, MA 
Grist, JT 
Schulte, Rolf 

Abstract

Incomplete fluid suppression on fluid-attenuated inversion-recovery 23Na-MRI (IR-23Na-MRI) was observed in three patients undergoing IR-23Na-MRI after gadolinium contrast injection, as part of a brain tumour imaging study. To evaluate this, 23Na-MRI T1 maps were acquired before and after injection of a gadolinium-based contrast agent on a grade IV glioma (GBM) patient, which showed a statistically significant change of 23Na-MRI T1 within the peritumoral oedema (p=0.0095). Gadolinium contrast-enhanced 23Na-MRI could potentially add further applications for sodium imaging and probe tumour tissue structure in new ways to investigate proliferation and treatment response.

Description

Keywords

Journal Title

Conference Name

The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition

Journal ISSN

Volume Title

Publisher

International Society for Magnetic Resonance in Medicine
Sponsorship
Cancer Research Uk (None)
MRC (1508766)