Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?
View / Open Files
Authors
Schulte, Rolf
Watts, Colin
Publication Date
2017-04-27Conference Name
The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition
Publisher
International Society for Magnetic Resonance in Medicine
Language
eng
Type
Conference Object
This Version
AM
Metadata
Show full item recordCitation
Riemer, F., McLean, M., Zaccagna, F., Grist, J., Schulte, R., Kaggie, J., Watts, C., et al. (2017). Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?. The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition. http://dev.ismrm.org/2017/2208.html
Abstract
Incomplete fluid suppression on fluid-attenuated inversion-recovery 23Na-MRI (IR-23Na-MRI) was observed in three
patients undergoing IR-23Na-MRI after gadolinium contrast injection, as part of a brain tumour imaging study. To evaluate this, 23Na-MRI T1 maps were acquired before and after injection of a gadolinium-based contrast agent on a grade IV glioma (GBM) patient, which showed a statistically significant change of 23Na-MRI T1 within the peritumoral oedema (p=0.0095). Gadolinium contrast-enhanced 23Na-MRI could potentially add further applications for sodium imaging and probe tumour tissue structure in new ways to investigate proliferation and treatment response.
Sponsorship
Cancer Research UK (16465)
MRC (1508766)
Identifiers
External link: http://dev.ismrm.org/2017/2208.html
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271562
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved