Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation?
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Seaman, Matthew NJ
Abstract
The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this long-established theory. Here, the evidence for and against a role for the retromer CSC in CIMPR endosome-to-Golgi retrieval is examined in the light of the new data that the SNX-BAR dimer is actually responsible for CIMPR retrieval.
Description
Keywords
CIMPR, Retromer, SNX-BAR, cargo-selection, endosome-to-Golgi retrieval, sorting motif, Carrier Proteins, Endosomes, Golgi Apparatus, Humans, Protein Transport, Vesicular Transport Proteins, trans-Golgi Network
Journal Title
Traffic
Conference Name
Journal ISSN
1398-9219
1600-0854
1600-0854
Volume Title
19
Publisher
Wiley
Publisher DOI
Sponsorship
Medical Research Council (MR/L007533/1)
Medical Research Council (G0701444)
Medical Research Council (G0700750)
Medical Research Council (G0701444)
Medical Research Council (G0700750)