Repository logo
 

Social recovery therapy in combination with early intervention services for enhancement of social recovery in patients with first-episode psychosis (SUPEREDEN3): a single-blind, randomised controlled trial

Published version
Peer-reviewed

Change log

Authors

Fowler, David 
Hodgekins, Jo 
French, Paul 
Marshall, Max 
Freemantle, Nick 

Abstract

SUMMARY Background: We conducted a randomised controlled trial to evaluate the efficacy of enhancing social recovery from First Episode Psychosis (FEP) by augmenting Early Intervention Service (EIS) provision with Social Recovery Therapy (SRT). The primary hypothesis was that SRT plus EIS would lead to improvements in social recovery. Methods: SUPEREDEN3 was an assessor blind randomised controlled trial. It was conducted at 4 specialist Early Intervention Services across the UK. Participants had (a) been clients of Early Intervention Services for 12-30 months; and (b) showed persistent and severe social disability defined as engaged in less than 30 hours per week of structured activity. Participants were randomised 1:1. Assessment of outcomes was conducted at baseline, 9 months (post intervention) and 15 month follow up. The primary outcome was time spent in structured activity at 9 months. The trial is registered (ISRCTN61621571). Findings: 75 (49%) of 154 participants were assigned to SRT plus EIS and 79 (51%) were assigned to EIS alone. At 9 months 143 participants (93%) provided data on the primary outcome. Randomisation to SRT plus EIS was associated with an increase in structured activity of 8.1 hours greater than EIS alone (95% CI 2.5 to 13.6; p = 0.0050). Jointly modelling loss to follow up and secondary outcomes provided supportive evidence of continued effects of SRT plus EIS. Interpretation: The findings show a clinically important benefit of enhanced social recovery for the SRT plus EIS group on the primary outcome of structured activity. Funding: National Institute for Health Research (NIHR).

Description

Keywords

32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Prevention, Brain Disorders, Mental Health, Serious Mental Illness, Clinical Trials and Supportive Activities, Rehabilitation, Clinical Research, 6.6 Psychological and behavioural, 6 Evaluation of treatments and therapeutic interventions, Mental health, Adolescent, Adult, Early Medical Intervention, Female, Humans, Interpersonal Relations, Male, Mental Health Services, Psychiatric Rehabilitation, Psychotic Disorders, Single-Blind Method, Social Skills, Treatment Outcome

Journal Title

LANCET PSYCHIATRY

Conference Name

Journal ISSN

2215-0374

Volume Title

5

Publisher

Elsevier BV
Sponsorship
National Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)