Spectral Diversity in Default Mode Network Connectivity Reflects Behavioral State.
Journal of cognitive neuroscience
Cambridge Center for Behavioral Studies
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Craig, M., Manktelow, A., Sahakian, B., Menon, D., & Stamatakis, E. (2018). Spectral Diversity in Default Mode Network Connectivity Reflects Behavioral State.. Journal of cognitive neuroscience, 30 (4), 526-539. https://doi.org/10.1162/jocn_a_01213
Default mode network (DMN) functional connectivity is thought to occur primarily in low frequencies (< 0.1 Hz), resulting in most studies removing high frequencies during data preprocessing. In contrast, subtractive task analyses include high frequencies, as these are thought to be task relevant. An emerging line of research explores resting fMRI data at higher frequency bands, examining the possibility that functional connectivity is a multi-band phenomenon. Furthermore, recent studies suggest DMN involvement in cognitive processing, however without a systematic investigation of DMN connectivity during tasks, its functional contribution to cognition cannot be fully understood. We bridged these concurrent lines of research by examining the contribution of high frequencies in the relationship between DMN and dorsal attention network (DAN) at rest and during task execution. Our findings revealed that the inclusion of high frequencies alters between network connectivity resulting in reduced anticorrelation and increased positive connectivity between DMN and DAN. Critically, increased positive connectivity was observed only during tasks suggesting an important role for high frequency fluctuations in functional integration. Moreover, within DMN connectivity during task execution correlated with reaction time only when high frequencies were included. These results show that DMN does not simply deactivate during task execution and suggest active recruitment while performing cognitively demanding paradigms.
Brain, Neural Pathways, Humans, Magnetic Resonance Imaging, Brain Mapping, Motor Activity, Attention, Reaction Time, Neuropsychological Tests, Rest, Adult, Middle Aged, Female, Male, Young Adult
Evelyn Trust (unknown)
External DOI: https://doi.org/10.1162/jocn_a_01213
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271818