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dc.contributor.authorJongsma, Hannah E
dc.contributor.authorGayer-Anderson, Charlotte
dc.contributor.authorLasalvia, Antonio
dc.contributor.authorQuattrone, Diego
dc.contributor.authorMulè, Alice
dc.contributor.authorSzöke, Andrei
dc.contributor.authorSelten, Jean-Paul
dc.contributor.authorTurner, Caitlin
dc.contributor.authorArango, Celso
dc.contributor.authorTarricone, Ilaria
dc.contributor.authorBerardi, Domenico
dc.contributor.authorTortelli, Andrea
dc.contributor.authorLlorca, Pierre-Michel
dc.contributor.authorde Haan, Lieuwe
dc.contributor.authorBobes, Julio
dc.contributor.authorBernardo, Miguel
dc.contributor.authorSanjuán, Julio
dc.contributor.authorSantos, José Luis
dc.contributor.authorArrojo, Manuel
dc.contributor.authorDel-Ben, Cristina Marta
dc.contributor.authorMenezes, Paulo Rossi
dc.contributor.authorMurray, Robin M
dc.contributor.authorRutten, Bart P
dc.contributor.authorJones, Peter B
dc.contributor.authorvan Os, Jim
dc.contributor.authorMorgan, Craig
dc.contributor.authorKirkbride, James B
dc.contributor.authorEuropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2 (EU-GEI WP2) Group
dc.description.abstractImportance: Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. Objectives: To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. Design, Setting, and Participants: An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catchment areas), Italy (3 catchment areas), the Netherlands (2 catchment areas), Spain (6 catchment areas), and Brazil (1 catchment area) with a first episode of nonorganic psychotic disorders (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes F20-F33) confirmed by the Operational Criteria Checklist. Denominator populations were estimated using official national statistics. Exposures: Age, sex, and racial/ethnic minority status were treated as a priori confounders. Latitude, population density, percentage unemployment, owner-occupied housing, and single-person households were treated as catchment area-level exposures. Main Outcomes and Measures: Incidence of nonorganic psychotic disorders (ICD-10 codes F20-F33), nonaffective psychoses (ICD-10 codes F20-F29), and affective psychoses (ICD-10 codes F30-F33) confirmed by the Operational Criteria Checklist. Results: A total of 2774 patients (1196 women and 1578 men; median age, 30.5 years [interquartile range, 23.0-41.0 years]) with incident cases of psychotic disorders were identified during 12.9 million person-years at risk (crude incidence, 21.4 per 100 000 person-years; 95% CI, 19.4-23.4 per 100 000 person-years). A total of 2183 patients (78.7%) had nonaffective psychotic disorders. After direct standardization for age, sex, and racial/ethnic minority status, an 8-fold variation was seen in the incidence of all psychotic disorders, from 6.0 (95% CI, 3.5-8.6) per 100 000 person-years in Santiago, Spain, to 46.1 (95% CI, 37.3-55.0) per 100 000 person-years in Paris, France. Rates were elevated in racial/ethnic minority groups (incidence rate ratio, 1.6; 95% CI, 1.5-1.7), were highest for men 18 to 24 years of age, and were lower in catchment areas with more owner-occupied homes (incidence rate ratio, 0.8; 95% CI, 0.7-0.8). Similar patterns were observed for nonaffective psychoses; a lower incidence of affective psychoses was associated with higher area-level unemployment (incidence rate ratio, 0.3; 95% CI, 0.2-0.5). Conclusions and Relevance: This study confirmed marked heterogeneity in risk for psychotic disorders by person and place, including higher rates in younger men, racial/ethnic minorities, and areas characterized by a lower percentage of owner-occupied houses.
dc.description.sponsorshipThe European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme. The Brazilian study was funded by grant 2012/0417-0 from the São Paulo Research Foundation. Dr Kirkbride is funded by the Wellcome Trust and grant 101272/Z/13/Z from the Royal Society. Ms Jongsma and Dr Jones are funded by the National Institute of Health Research Collaboration of Leadership in Applied Health Research and Care East of England.
dc.publisherAmerican Medical Association
dc.rightsAttribution 4.0 International
dc.titleTreated Incidence of Psychotic Disorders in the Multinational EU-GEI Study
prism.publicationNameJAMA Psychiatry
dc.contributor.orcidJongsma, Hannah [0000-0001-6346-5903]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission (241909)

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