Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species
Accepted version
Peer-reviewed
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Abstract
jats:pA new three-component coupling protocol for preparation of functionalized indolines, with a high degree of diastereoselectivity, has been developed. The protocol is based on the in situ homologation of vinyl boronic acids to allylboronic acids, using TMSCHN2 as carbon source, and subsequent coupling reaction with indoles to give 2-substituted indolines. The scope of the method was exemplified in several examples.</jats:p>
Description
Keywords
allyl boronic species, indolines, vinyl boronic acids, diastereoselective, multicomponent reaction
Journal Title
Synlett
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Journal ISSN
0936-5214
1437-2096
1437-2096
Volume Title
29
Publisher
Georg Thieme Verlag KG
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Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
São Paulo Research Foundation – FAPESP (awards No. 2014/26378-2 and 2014/25770-6 award No. 2016/05630-0),
CNPq (award No. 453862/2014-4),
Croucher Foundation