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dc.contributor.authorBlock, Matthew S
dc.contributor.authorVierkant, Robert A
dc.contributor.authorRambau, Peter F
dc.contributor.authorWinham, Stacey J
dc.contributor.authorWagner, Philipp
dc.contributor.authorTraficante, Nadia
dc.contributor.authorTołoczko, Aleksandra
dc.contributor.authorTiezzi, Daniel G
dc.contributor.authorTaran, Florin Andrei
dc.contributor.authorSinn, Peter
dc.contributor.authorSieh, Weiva
dc.contributor.authorSharma, Raghwa
dc.contributor.authorRothstein, Joseph H
dc.contributor.authorRamón Y Cajal, Teresa
dc.contributor.authorPaz-Ares, Luis
dc.contributor.authorOszurek, Oleg
dc.contributor.authorOrsulic, Sandra
dc.contributor.authorNess, Roberta B
dc.contributor.authorNelson, Gregg
dc.contributor.authorModugno, Francesmary
dc.contributor.authorMenkiszak, Janusz
dc.contributor.authorMcGuire, Valerie
dc.contributor.authorMcCauley, Bryan M
dc.contributor.authorMack, Marie
dc.contributor.authorLubiński, Jan
dc.contributor.authorLongacre, Teri A
dc.contributor.authorLi, Zheng
dc.contributor.authorLester, Jenny
dc.contributor.authorKennedy, Catherine J
dc.contributor.authorKalli, Kimberly R
dc.contributor.authorJung, Audrey Y
dc.contributor.authorJohnatty, Sharon E
dc.contributor.authorJimenez-Linan, Mercedes
dc.contributor.authorJensen, Allan
dc.contributor.authorIntermaggio, Maria P
dc.contributor.authorHung, Jillian
dc.contributor.authorHerpel, Esther
dc.contributor.authorHernandez, Brenda Y
dc.contributor.authorHartkopf, Andreas D
dc.contributor.authorHarnett, Paul R
dc.contributor.authorGhatage, Prafull
dc.contributor.authorGarcía-Bueno, José M
dc.contributor.authorGao, Bo
dc.contributor.authorFereday, Sian
dc.contributor.authorEilber, Ursula
dc.contributor.authorEdwards, Robert P
dc.contributor.authorde Sousa, Christiani B
dc.contributor.authorde Andrade, Jurandyr M
dc.contributor.authorChudecka-Głaz, Anita
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorCazorla, Alicia
dc.contributor.authorBrucker, Sara Y
dc.contributor.authorAustralian Ovarian Cancer Study Group
dc.contributor.authorAlsop, Jennifer
dc.contributor.authorWhittemore, Alice S
dc.contributor.authorSteed, Helen
dc.contributor.authorStaebler, Annette
dc.contributor.authorMoysich, Kirsten B
dc.contributor.authorMenon, Usha
dc.contributor.authorKoziak, Jennifer M
dc.contributor.authorKommoss, Stefan
dc.contributor.authorKjaer, Susanne K
dc.contributor.authorKelemen, Linda E
dc.contributor.authorKarlan, Beth Y
dc.contributor.authorHuntsman, David G
dc.contributor.authorHøgdall, Estrid
dc.contributor.authorGronwald, Jacek
dc.contributor.authorGoodman, Marc T
dc.contributor.authorGilks, Blake
dc.contributor.authorGarcía, María José
dc.contributor.authorFasching, Peter A
dc.contributor.authorde Fazio, Anna
dc.contributor.authorDeen, Suha
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorCandido Dos Reis, Francisco J
dc.contributor.authorCampbell, Ian G
dc.contributor.authorBrenton, James D
dc.contributor.authorBowtell, David D
dc.contributor.authorBenítez, Javier
dc.contributor.authorPharoah, Paul DP
dc.contributor.authorKöbel, Martin
dc.contributor.authorRamus, Susan J
dc.contributor.authorGoode, Ellen L
dc.date.accessioned2018-02-22T13:33:26Z
dc.date.available2018-02-22T13:33:26Z
dc.date.issued2018-03
dc.identifier.issn0025-6196
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273426
dc.description.abstractOBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P<.001 for both). In HGSOC, strong MyD88 expression was modestly associated with shortened overall survival (hazard ratio [HR], 1.13; 95% CI, 1.01-1.26; P=.04) but was also associated with advanced stage (P<.001). The expression of TLR4 was not associated with survival. In low-grade serous ovarian cancer (LGSOC), strong expression of both MyD88 and TLR4 was associated with favorable survival (HR [95% CI], 0.49 [0.29-0.84] and 0.44 [0.21-0.89], respectively; P=.009 and P=.02, respectively). CONCLUSION: Results are consistent with an association between strong MyD88 staining and advanced stage and poorer survival in HGSOC and demonstrate correlation between strong MyD88 and TLR4 staining and improved survival in LGSOC, highlighting the biological differences between the 2 serous histotypes.
dc.format.mediumPrint
dc.languageeng
dc.publisherElsevier BV
dc.subjectAustralian Ovarian Cancer Study Group
dc.subjectHumans
dc.subjectOvarian Neoplasms
dc.subjectTissue Array Analysis
dc.subjectImmunohistochemistry
dc.subjectSurvival Analysis
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectToll-Like Receptor 4
dc.subjectMyeloid Differentiation Factor 88
dc.subjectBiomarkers, Tumor
dc.subjectCarcinoma, Ovarian Epithelial
dc.titleMyD88 and TLR4 Expression in Epithelial Ovarian Cancer.
dc.typeArticle
prism.endingPage320
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameMayo Clin Proc
prism.startingPage307
prism.volume93
dc.identifier.doi10.17863/CAM.20456
dcterms.dateAccepted2017-10-16
rioxxterms.versionofrecord10.1016/j.mayocp.2017.10.023
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidBrenton, James [0000-0002-5738-6683]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1942-5546
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idNational Institutes of Health (NIH) (via H Lee Moffitt Cancer Center & Research Institute) (SUBAWARD # 10-15915-01-03-G2)
pubs.funder-project-idCancer Research Uk (None)
cam.orpheus.successThu Jan 30 12:59:23 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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