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Engineering the Drosophila Genome for Developmental Biology.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Korona, Dagmara 
Russell, Steven 

Abstract

The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function.

Description

Keywords

CRISPR-Cas9, Drosophila, genome engineering, protein tagging

Journal Title

J Dev Biol

Conference Name

Journal ISSN

2221-3759
2221-3759

Volume Title

5

Publisher

MDPI AG
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/N007069/1)
BBSRC (via University of Manchester) (R116574-LLM)
Biotechnology and Biological Sciences Research Council (BB/L002817/1)
BBSRC BB/L002817/1 and BB/N007069/1