Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line.
Published version
Peer-reviewed
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Type
Article
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Abstract
Inherited mutations in the mitochondrial (mt)DNA are a major cause of human disease, with approximately 1 in 5000 people affected by one of the hundreds of identified pathogenic mtDNA point mutations or deletions. Due to the severe, and often untreatable, symptoms of many mitochondrial diseases, identifying how these mutations are inherited from one generation to the next has been an area of intense research in recent years. Despite large advances in our understanding of this complex process, many questions remain unanswered, with one of the most hotly debated being whether or not purifying selection acts against pathogenic mutations during germline development.
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Keywords
Animals, DNA, Mitochondrial, Female, Germ Cells, Humans, Inheritance Patterns, Mammals, Mitochondria, Mitochondrial Diseases, Mutation, Selection, Genetic
Journal Title
Dev Growth Differ
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Journal ISSN
0012-1592
1440-169X
1440-169X
Volume Title
60
Publisher
Wiley
Publisher DOI
Sponsorship
Wellcome Trust (101876/Z/13/Z)
Wellcome Trust (101876/B/13/A)
Wellcome Trust (101876/B/13/A)