NLRP3 inflammasome pathways in atherosclerosis
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Li, X., Mallat, Z., & Baldrighi, M. (2017). NLRP3 inflammasome pathways in atherosclerosis. Atherosclerosis, 267 127-138. https://doi.org/10.1016/j.atherosclerosis.2017.10.027
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (NLRP3) was important for atherogenesis, a substantial number of studies have emerged addressing the basic mechanisms of inflammasome activation and their relevance to atherosclerosis. In this review, we introduce the basic cellular and molecular mechanisms of NLRP3 inflammasome activation, and discuss the current findings and therapeutic strategies that target NLRP3 inflammasome activation during the development and progression of atherosclerosis.
atherosclerosis, NLRP3 inflammasome, ASC, Caspase-1, IL-1β
We would like to thank British Heart Foundation (BHF) for supporting our work. MB is supported by BHF Ph.D studentship grant to XL (FS/17/5/32531); ZM is supported by BHF chair grant to ZM (CH/10/001/27642); and XL is supported by BHF fellowship grant to XL (FS/14/28/30713).
British Heart Foundation (CH/10/001/27642)
British Heart Foundation (FS/14/28/30713)
British Heart Foundation (1659)
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External DOI: https://doi.org/10.1016/j.atherosclerosis.2017.10.027
This record's URL: https://www.repository.cam.ac.uk/handle/1810/273548
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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