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dc.contributor.authorLi, Xuanen
dc.contributor.authorMallat, Zen
dc.contributor.authorBaldrighi, Men
dc.date.accessioned2018-02-26T14:16:55Z
dc.date.available2018-02-26T14:16:55Z
dc.date.issued2017-12-01en
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273548
dc.description.abstractAtherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (NLRP3) was important for atherogenesis, a substantial number of studies have emerged addressing the basic mechanisms of inflammasome activation and their relevance to atherosclerosis. In this review, we introduce the basic cellular and molecular mechanisms of NLRP3 inflammasome activation, and discuss the current findings and therapeutic strategies that target NLRP3 inflammasome activation during the development and progression of atherosclerosis.
dc.description.sponsorshipWe would like to thank British Heart Foundation (BHF) for supporting our work. MB is supported by BHF Ph.D studentship grant to XL (FS/17/5/32531); ZM is supported by BHF chair grant to ZM (CH/10/001/27642); and XL is supported by BHF fellowship grant to XL (FS/14/28/30713).
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectatherosclerosisen
dc.subjectNLRP3 inflammasomeen
dc.subjectASCen
dc.subjectCaspase-1en
dc.subjectIL-1βen
dc.titleNLRP3 inflammasome pathways in atherosclerosisen
dc.typeArticle
prism.endingPage138
prism.publicationDate2017en
prism.publicationNameAtherosclerosisen
prism.startingPage127
prism.volume267en
dc.identifier.doi10.17863/CAM.20621
dcterms.dateAccepted2017-10-19en
rioxxterms.versionofrecord10.1016/j.atherosclerosis.2017.10.027en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-12-01en
dc.contributor.orcidLi, Xuan [0000-0002-0754-3011]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (CH/10/001/27642)
pubs.funder-project-idBritish Heart Foundation (FS/14/28/30713)
pubs.funder-project-idBritish Heart Foundation (1659)
cam.issuedOnline2017-10-22en
cam.orpheus.successThu Jan 30 12:59:17 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International