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dc.contributor.authorPhipps, Roberten
dc.contributor.authorGenov, Georgien
dc.contributor.authorMihai, Madalinaen
dc.date.accessioned2018-02-27T13:31:37Z
dc.date.available2018-02-27T13:31:37Z
dc.date.issued2018-01-07en
dc.identifier.issn0306-0012
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273580
dc.description.abstractThe elaboration of simple arenes in order to access more complex substitution patterns is a crucial endeavor for synthetic chemists, given the central role that aromatic rings play in all manner of important molecules. Classical methods are now routinely used alongside stoichiometric organometallic approaches and, most recently, transition metal catalysis in the range of methodologies that are available to elaborate arene C-H bonds. Regioselectivity is an important consideration when selecting a method and, of all those available, it is arguably those that target the meta postion that are fewest in number. The rapid development of transition metal-catalysed C-H bond functionalisation over the last few decades has opened new possibilities for meta-selective C-H functionalisation through the diverse reactivity of transition metals and their compatibility with a wide range of directing groups. The pace of discovery of such processes has grown rapidly in the last five years in particularly and it is the purpose of this review to examine these but in doing so to place the focus on metals other than palladium, the specific contributions of which have been very recently reviewed elsewhere. It is hoped this will serve to highlight to the reader the breadth of current strategies and mechanisms that have been used to tackle this challenge, which may inspire further progress in the field.
dc.description.sponsorshipWe are grateful to the Royal Society for a University Research Fellowship (R.J.P.), AstraZeneca for a PhD studentship (M.T.M.) through the AZ-Cambridge PhD Program and the EPSRC (G.R.G, EP/N005422/1).
dc.languageengen
dc.publisherRoyal Society of Chemistry
dc.titleAccess to the Meta Position of Arenes through Transition Metal Catalysed C-H Bond Functionalisation: A Focus on Metals Other Than Palladiumen
dc.typeArticle
prism.endingPage171
prism.issueIdentifier1en
prism.publicationDate2018en
prism.publicationNameChemical Society Reviewsen
prism.startingPage149
prism.volume47en
dc.identifier.doi10.17863/CAM.20651
dcterms.dateAccepted2017-10-15en
rioxxterms.versionofrecord10.1039/C7CS00637Cen
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01-07en
dc.contributor.orcidPhipps, Robert [0000-0002-7383-5469]
dc.contributor.orcidGenov, Georgi [0000-0002-8039-3160]
dc.identifier.eissn1460-4744
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/N005422/1)
pubs.funder-project-idRoyal Society (uf130004)
cam.issuedOnline2017-10-26en
rioxxterms.freetoread.startdate2018-10-26


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