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dc.contributor.authorNightingale, Claire Men
dc.contributor.authorRudnicka, Alicja Ren
dc.contributor.authorKerry-Barnard, Sarah Ren
dc.contributor.authorDonin, Angela Sen
dc.contributor.authorBrage, Sorenen
dc.contributor.authorWestgate, Kateen
dc.contributor.authorEkelund, Ulfen
dc.contributor.authorCook, Derek Gen
dc.contributor.authorOwen, Christopher Gen
dc.contributor.authorWhincup, Peter Hen
dc.date.accessioned2018-03-02T12:44:48Z
dc.date.available2018-03-02T12:44:48Z
dc.date.issued2018-06en
dc.identifier.issn1399-543X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273681
dc.description.abstractAbstract Background: The relationships between physical fitness and risk markers for type 2 diabetes (T2D) in children and the contribution to ethnic differences in these risk markers have been little studied. We examined associations between physical fitness and early risk markers for T2D and cardiovascular disease in 9-10 year-old UK children. Methods: Cross-sectional study of 1445 9-10 year-old UK children of South Asian, black African-Caribbean and white European origin. A fasting blood sample was used for measurement of insulin, glucose (from which HOMA-insulin resistance (IR) was derived), HbA1c, urate, C-reactive protein (CRP) and lipids. Measurements of blood pressure (BP) and fat mass index (FMI) were made; physical activity was measured by accelerometry. Estimated VO2 max was derived from a submaximal fitness step test. Associations were estimated using multilevel linear regression. Results: Higher VO2 max was associated with lower FMI, insulin, HOMA-IR, HbA1c, glucose, urate, CRP, triglycerides, LDL-cholesterol, BP and higher HDL-cholesterol. Associations were reduced by adjustment for FMI, but those for insulin, HOMA-IR, glucose, urate, CRP, triglycerides and BP remained statistically significant. Higher levels of insulin and HOMA-IR in South Asian children were partially explained by lower levels of VO2 max compared to white Europeans, accounting for 11% of the difference. Conclusions: Physical fitness is associated with risk markers for T2D and CVD in children, which persist after adjustment for adiposity. Higher levels of IR in South Asians are partially explained by lower physical fitness levels compared to white Europeans. Improving physical fitness may provide scope for reducing risks of T2D.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHumansen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectRisk Factorsen
dc.subjectCross-Sectional Studiesen
dc.subjectAge Factorsen
dc.subjectAge of Onseten
dc.subjectPhysical Fitnessen
dc.subjectChilden
dc.subjectEthnic Groupsen
dc.subjectEnglanden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectBiomarkersen
dc.titleThe contribution of physical fitness to individual and ethnic differences in risk markers for type 2 diabetes in children: The Child Heart and Health Study in England (CHASE).en
dc.typeArticle
prism.endingPage610
prism.issueIdentifier4en
prism.publicationDate2018en
prism.publicationNamePediatric diabetesen
prism.startingPage603
prism.volume19en
dc.identifier.doi10.17863/CAM.20735
dcterms.dateAccepted2017-12-13en
rioxxterms.versionofrecord10.1111/pedi.12637en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidNightingale, Claire M [0000-0002-4803-7617]
dc.contributor.orcidRudnicka, Alicja R [0000-0003-0369-8574]
dc.contributor.orcidDonin, Angela S [0000-0002-8238-9923]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidWestgate, Kate [0000-0002-0283-3562]
dc.contributor.orcidCook, Derek G [0000-0002-9723-5759]
dc.contributor.orcidOwen, Christopher G [0000-0003-1135-5977]
dc.contributor.orcidWhincup, Peter H [0000-0002-5589-4107]
dc.identifier.eissn1399-5448
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
cam.orpheus.successThu Jan 30 12:58:20 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International