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dc.contributor.authorLansdall, Claireen
dc.contributor.authorCoyle-Gilchrist, Ian TSen
dc.contributor.authorJones, Simonen
dc.contributor.authorVázquez Rodríguez, Patriciaen
dc.contributor.authorWilcox, Aliciaen
dc.contributor.authorWehmann, Eileenen
dc.contributor.authorDick, Katrina Men
dc.contributor.authorRobbins, Trevoren
dc.contributor.authorRowe, Jamesen
dc.date.accessioned2018-03-05T17:19:06Z
dc.date.available2018-03-05T17:19:06Z
dc.date.issued2018-03en
dc.identifier.issn0028-3878
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273753
dc.description.abstractObjectives: To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion weighted imaging and data from the Pick’s disease and Progressive supranuclear palsy Prevalence and INcidence study (PiPPIN). We included behavioral and language variants of frontotemporal dementia, corticobasal syndrome and progressive supranuclear palsy. Methods: Seventy patients and 30 controls underwent diffusion tensor imaging at 3T after detailed assessment of apathy and impulsivity. We used tract-based spatial statistics of fractional anisotropy and mean diffusivity, correlating with eight orthogonal dimensions of apathy and impulsivity derived from a principal component analysis of neuropsychological, behavioral and questionnaire measures. Results: Three components were associated with significant white matter tract abnormalities. Carer rated change in everyday skills, self-care and motivation correlated with widespread changes in dorsal frontoparietal and corticospinal tracts; while carer observations of impulsive-apathetic and challenging behaviors revealed disruption in ventral frontotemporal tracts. Objective neuropsychological tests of cognitive control, reflection impulsivity and reward responsiveness were associated with focal changes in the right frontal lobe and pre-supplementary motor area. These changes were observed across clinical diagnostic groups, and were not restricted to the disorders for which diagnostic criteria include apathy and impulsivity. Conclusions: The current study provides evidence of distinct structural network changes in white matter associated with different neurobehavioral components of apathy and impulsivity across the diverse spectrum of syndromes and pathologies associated with frontotemporal lobar degeneration.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWolters Kluwer Health
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBrainen
dc.subjectHumansen
dc.subjectSupranuclear Palsy, Progressiveen
dc.subjectDiffusion Magnetic Resonance Imagingen
dc.subjectImpulsive Behavioren
dc.subjectNeuropsychological Testsen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectFrontotemporal Lobar Degenerationen
dc.subjectApathyen
dc.subjectWhite Matteren
dc.titleWhite matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes.en
dc.typeArticle
prism.endingPagee1076
prism.issueIdentifier12en
prism.publicationDate2018en
prism.publicationNameNeurologyen
prism.startingPagee1066
prism.volume90en
dc.identifier.doi10.17863/CAM.17132
dc.identifier.doi10.17863/CAM.17132
dcterms.dateAccepted2017-12-21en
rioxxterms.versionofrecord10.1212/wnl.0000000000005175en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-03en
dc.contributor.orcidCoyle-Gilchrist, Ian TS [0000-0001-8887-1801]
dc.contributor.orcidJones, Simon [0000-0001-9695-0702]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1526-632X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idJames S McDonnell Foundation (220020289)
pubs.funder-project-idEvelyn Trust (46722)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idPSP Association (unknown)
pubs.funder-project-idMRC (MR/P01271X/1)
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M009041/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M024873/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
cam.orpheus.successThu Jan 30 12:59:07 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International