Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.
The British journal of radiology
British Institute of Radiology
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Zaccagna, F., Grist, J., Deen, S., Woitek, R., Lechermann, L., McLean, M., Basu, B., & et al. (2018). Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.. The British journal of radiology, 91 (1085), 20170688. https://doi.org/10.1259/bjr.20170688
Glucose metabolism in tumours is reprogrammed away from oxidative metabolism, even in the presence of oxygen. Non-invasive imaging techniques can probe these alterations in cancer metabolism providing tools to detect tumours and their response to therapy. Although Positron Emission Tomography with [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG PET) is an established clinical tool to probe cancer metabolism, it has poor spatial resolution and soft tissue contrast, utilises ionizing radiation and only probes glucose uptake and phosphorylation and not further downstream metabolism. Magnetic Resonance Spectroscopy (MRS) has the capability to non-invasively detect and distinguish molecules within tissue but has low sensitivity and can only detect selected nuclei. Dynamic Nuclear Polarisation (DNP) is a technique which greatly increases the signal-to-noise ratio (SNR) achieved with MR by significantly increasing nuclear spin polarisation and this method has now been translated into human imaging. This review provides a brief overview of this process, also termed Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (HP 13C-MRSI), its applications in pre-clinical imaging, an outline of the current human trials that are ongoing, as well as future potential applications in oncology.
Humans, Neoplasms, Carbon Isotopes, Glucose, Radiopharmaceuticals, Magnetic Resonance Spectroscopy
Cancer Research UK (16628)
PROSTATE CANCER UK (PA14-012)
Multiple Sclerosis Society (35)
Cancer Research UK (unknown)
Cancer Research UK (C14303_do not transfer)
Cancer Research UK (16465)
External DOI: https://doi.org/10.1259/bjr.20170688
This record's URL: https://www.repository.cam.ac.uk/handle/1810/273810