Testicular cancer in 2017: Sequencing advances understanding.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Murray, Matthew J
Turnbull, Clare
Abstract
Our biological understanding of TGCTs has been improved using sequencing, and molecular profiles associated with the genomic evolution and development of cisplatin resistance have been identified. The genomics of variants underpinning TGCT predisposition is being delineated. Studies of circulating microRNAs have demonstrated their potential for noninvasive diagnosis and disease monitoring.
Description
Keywords
Biomarkers, Tumor, Drug Resistance, Neoplasm, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, MicroRNAs, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Exome Sequencing
Journal Title
Nat Rev Urol
Conference Name
Journal ISSN
1759-4812
1759-4820
1759-4820
Volume Title
15
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Isaac Newton Trust (1540 (f))
St Baldrick's Foundation (via Dana-Farber Cancer Institute) (2015-0743)
St Baldrick's Foundation (via Dana-Farber Cancer Institute) (2015-0743)