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dc.contributor.authorHunter, Sallyen
dc.contributor.authorGrbic-Smailagic, Nadjijaen
dc.contributor.authorBrayne, Carolen
dc.date.accessioned2018-03-14T12:33:05Z
dc.date.available2018-03-14T12:33:05Z
dc.date.issued2018-01en
dc.identifier.issn1387-2877
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/273991
dc.description.abstractAlzheimer disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid based randomized controlled trials to change the course of AD, there are growing calls for a re-evaluation of basic AD research. Epidemiology offers one approach to integrating the available evidence. Here we examine relationships between evidence from population-based, clinicopathological studies of brain ageing and a range of hypotheses from all areas of AD research. We identify various problems, including a lack of systematic approach to measurement of clinical and neuropathological factors associated with dementia in experimental and clinical settings, poor understanding of the strengths and weaknesses of different observational, and experimental designs, a lack of clarity in relation to disease definitions from the clinical, neuropathological and molecular perspectives, inadequate characterization of brain ageing in the human population, difficulties in translation between laboratory based and population based evidence bases, and a lack of communication between different sections of the dementia research community. Population studies highlight complexity and predict that therapeutic approaches based on single disease features will not be successful. Better characterization of brain ageing in the human population is urgently required to select biomarkers and therapeutic targets that are meaningful to human disease. The generation of detailed and reliable evidence must be addressed before progress towards therapeutic interventions can be made.
dc.format.mediumPrinten
dc.languageengen
dc.publisherIOS Press
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectDementiaen
dc.subjectBiomedical Researchen
dc.titleDementia Research: Populations, Progress, Problems, and Predictions.en
dc.typeArticle
prism.endingPageS143
prism.issueIdentifiers1en
prism.publicationDate2018en
prism.publicationNameJournal of Alzheimer's disease : JADen
prism.startingPageS119
prism.volume64en
dc.identifier.doi10.17863/CAM.21062
dcterms.dateAccepted2017-10-23en
rioxxterms.versionofrecord10.3233/jad-179927en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidHunter, Sally [0000-0002-8063-6556]
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.identifier.eissn1875-8908
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idPaul G Allen Family Foundation (12076)


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