Repository logo
 

Regulating needs: Exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Sferruzzi-Perri, Amanda Nancy 

Abstract

During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function.

Description

Keywords

Environmental manipulation, Fetal growth, Hypoxia, IGF, Nutrition, Oxygen supply, Placental nutrient transport, Pregnancy, Signalling, Animals, Female, Humans, Insulin-Like Growth Factor II, Maternal-Fetal Exchange, Placenta, Placentation, Pregnancy, Signal Transduction

Journal Title

Placenta

Conference Name

Journal ISSN

0143-4004
1532-3102

Volume Title

64 Suppl 1

Publisher

Elsevier BV