Importance of vesicle release stochasticity in neuro-spike communication.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
MetadataShow full item record
Ramezani, H., & Akan, O. (2017). Importance of vesicle release stochasticity in neuro-spike communication.. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2017 3343-3347. https://doi.org/10.1109/embc.2017.8037572
Aim of this paper is proposing a stochastic model for vesicle release process, a part of neuro-spike communication. Hence, we study biological events occurring in this process and use microphysiological simulations to observe functionality of these events. Since the most important source of variability in vesicle release probability is opening of voltage dependent calcium channels (VDCCs) followed by influx of calcium ions through these channels, we propose a stochastic model for this event, while using a deterministic model for other variability sources. To capture the stochasticity of calcium influx to pre-synaptic neuron in our model, we study its statistics and find that it can be modeled by a distribution defined based on Normal and Logistic distributions.
Neurons, Calcium, Calcium Channels, Probability, Stochastic Processes, Models, Neurological
This work was supported in part by ERC project MINERVA (ERC-2013- CoG #616922), EU project CIRCLE (EU-H2020-FET-Open #665564), and TU˘ BI˙TAK graduate scholarship program (BIDEB-2215). 1MCell development is supported by the NIGMS-funded (P41GM103712) National Center for Multiscale Modeling of Biological Systems (MMBioS).
European Commission FP7 ERC Consolidator Grant (616922)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (665564)
External DOI: https://doi.org/10.1109/embc.2017.8037572
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274069