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Importance of vesicle release stochasticity in neuro-spike communication.

Accepted version
Peer-reviewed

Type

Conference Object

Change log

Authors

Akan, Ozgur B 

Abstract

Aim of this paper is proposing a stochastic model for vesicle release process, a part of neuro-spike communication. Hence, we study biological events occurring in this process and use microphysiological simulations to observe functionality of these events. Since the most important source of variability in vesicle release probability is opening of voltage dependent calcium channels (VDCCs) followed by influx of calcium ions through these channels, we propose a stochastic model for this event, while using a deterministic model for other variability sources. To capture the stochasticity of calcium influx to pre-synaptic neuron in our model, we study its statistics and find that it can be modeled by a distribution defined based on Normal and Logistic distributions.

Description

Keywords

Calcium, Calcium Channels, Models, Neurological, Neurons, Probability, Stochastic Processes

Journal Title

Annu Int Conf IEEE Eng Med Biol Soc

Conference Name

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Journal ISSN

1557-170X
2694-0604

Volume Title

2017

Publisher

IEEE
Sponsorship
European Research Council (616922)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (665564)
This work was supported in part by ERC project MINERVA (ERC-2013- CoG #616922), EU project CIRCLE (EU-H2020-FET-Open #665564), and TU˘ BI˙TAK graduate scholarship program (BIDEB-2215). 1MCell development is supported by the NIGMS-funded (P41GM103712) National Center for Multiscale Modeling of Biological Systems (MMBioS).